Richard Sprague

Technology. Personal Science. Microbiome. Quantified Self. #DeSci. China 中国 Japan 日本. Longevity. Linguistics. Heideggerian AI richardsprague.eth

[Richard Sprague @sprague]

@WillManidis @hkanji Years ago, when I carefully measured such things, I calculated that the most reliable predictor of my retention for foreign vocabulary was the number of times I opened the (paper) dictionary to (re)look up the word. There just are no shortcuts.

[Richard Sprague @sprague]

Yup, I find Zipf characteristics in my own app and phone usage. Claude + ActivityWatch makes analysis like this trivial https://t.co/DJ8un39yAY

[Richard Sprague @sprague]

I used to read 50-100 books / year, but now I maybe read 5. AI, including “vibe-reading” is just a more productive use of my time. https://t.co/1x6cx2bJft @KlingBlog

[Richard Sprague @sprague]

@mkaeberlein Please continue your podcast!

[Richard Sprague @sprague]

I tested the physician-grade @EvidenceOpen AI-driven clinical chatbot against Claude. Yes, it's nice that OpenEvidence uses top journals but I concluded that Claude is better for personal scientists. https://t.co/EFVECp2v3p

[Richard Sprague @sprague]

I've known for years that I'll feel more rested all day when I wake up with a low resting heart rate (RHR), but how can I reliably get there? I've been feeding a ton of detailed information into Claude the last few weeks and to my surprise it found one important driver I hadn't considered: the amount of protein I ate the day before.

[Richard Sprague @sprague]

via: https://t.co/sgwKVQPP70?

[Richard Sprague @sprague]

I'm not quite ready to bet on this possibility but IMHO those open models are awfully good

[Dave Friedman @friedmandave]

Hard to see how any of the ai providers have any kind of moat. Claude is as per usual down so I just switched to @grok and ran my query through it. The result was more than sufficient and I solved my problem while Dario fails to populate his data centers with sufficient numbers of geniuses.

[Richard Sprague @sprague]

I just claimed my .agent domain and joined the .agent community! get yours now and help shape the future of autonomous agents https://t.co/b7GOLf8yR9 @agentcommunity_

[Richard Sprague @sprague]

Another useless genetics report from @23andme . Why pay $100 to see if you _might_ be at risk when a $20 blood test can tell you for sure.

[Richard Sprague @sprague]

You’ve been wearing a fitness tracker for years. Isn’t it time to make a thorough long-term analysis with actionable, non-obvious conclusions? https://t.co/qnDM47bLPC

[Richard Sprague @sprague]

“Beware of unearned wisdom” - Carl Jung

[Bryan Johnson @bryan_johnson]

This was the most profound experience of my life. I am stunned beyond comprehension. This molecule is without peer.

The 27mg dose opened up what felt like pure consciousness and intelligence. A majestic reveal of existence itself. In all its incomprehensible glory and majesty. It is impossible to explain with words. Whatever you imagine, multiply it by 1,000 and then add infinite width and depth and dimensions.

But entrance was not granted without prerequisite. Existence demanded that I submit. That I say yes; without attachment and without condition. Yes to existence; yes to the dissolution of self; yes to release control; yes, to all.

My ego registered the ask and panicked. It wanted control. It was desperate for control. It pleaded to escape from the torrent of light and essence that threatened to rip my sanity into chards. The urge to eject was overwhelming. Terror thundered throughout my mind and body.

It took everything within me to release. I overcame and was treated with bliss that defies imagination. A euphoria colored with perfect harmony of all things. An orchestra of essence washed over me and swept me up in dance. It was home. The highest aspiration of intelligent life. For some reason, stored and tucked away as the ultimate prize.

A single concept emerged in omnipresence: we cannot grok the preciousness of our existence. Yet it is everything we’ve ever wanted and more. The state we long for without knowing it exists. This caused me great pain and heartache.

A swell of loyalty and devotion emerged inside me, pledging allegiance to existence. To become a warrior and caretaker of life on earth. To protect at any cost the candle of consciousness that has miraculously emerged in this part of the galaxy.

What awaits will wipe all your tears, soothe all your sorrows, and infinitely exceed your wants.

[Richard Sprague @sprague]

You have a very high bar for recognizing voter fraud. I bet you personally know (1) parents who fill in the ballots of their out-of-state college students, (2) spouses who do whatever the other spouse tells them because they fill it out together, (3) other examples when it's not really a secret ballot.

[Richard Sprague @sprague]

re: https://t.co/W1RCxPhZK5

[Richard Sprague @sprague]

Inevitably people will need to make peace with AI-generated writing. As LLMs get better and better, the commitment to "original creative expression and storytelling" will fade as we prioritize good writing regardless of the source.

[Richard Sprague @sprague]

see details in Personal Science Week: https://t.co/uIPDm66DF0

[Richard Sprague @sprague]

I tried this popular ketone "energy-shot" and measured my ketones afterwards. Result: bubkas, nada, zilch. The reason: it's a fine drink, I suppose, but for people with my genes it does nothing. 1/2

[Richard Sprague @sprague]

Human challenge trials! Volunteers agree to be infected and try some new therapeutic -- it's a thing. I wonder how the rest of us can volunteer? @shelbynewsad . https://t.co/wo23sOBT8b

[Richard Sprague @sprague]

Tons of new food products at @NatProdExpo last week, but I was most impressed by how Claude improved my workflow at big trade conferences: upload photos from each booth and auto-generate a summary https://t.co/R8UpTTbRgn

[Richard Sprague @sprague]

@BobTroia @ouraring @WHOOP Woah!