Sam Sgrizzi

Molecular Biology Graduate Student @UW | Previously AbuGoot lab @HarvardMed @MIT

[Kaiyi Jiang @idmjky]

Thrilled to share that EVOLVEpro is now published @ScienceMagazine Since our preprint, we now demonstrate low-N eningeering of both antibody and enzymes. We hope this model will broadly useful to the protein engineering field. https://t.co/vMzLFNkcnD

[Jonathan Gootenberg @jgooten]

Directed evolution won a Nobel prize by unlocking new protein functions

How can we augment evolution to engineer proteins 10-100 times better? By using large language models!

Here we present EVOLVEpro, an LLM for accelerated protein evolution

https://t.co/lxFRFVEt2Q 1/

[Sam Sgrizzi @ssgriz]

@zhaoweiasu @connorjtou @biorxivpreprint @FerreiraSilvaJ 🤖

[Jonathan Gootenberg @jgooten]

CRISPR nucleases have been transformative. What if there were similar RNA-programmed nucleases in eukaryotic genomes?

Turns out, they are abundant (>3500) and functional! Today we share findings on novel RNA-guided DNA nucleases in eukaryotes.

https://t.co/en30DMvvPc

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