Simon P. Shen

[Nature Methods @naturemethods]

TDAC-seq is a method for targeted chromatin accessibility profiling that uses cytidine deaminases and long-read sequencing to resolve the effects of CRISPR edits on single chromatin fibers.
@brian_b_liau @heejin_roh @sshen8 @YanHu41082612

https://t.co/KxVbE6iPnx

[Brian Liau @brian_b_liau]

Today in @naturemethods we present TDAC-seq, a method to profile chromatin accessibility across long chromatin fibers at targeted loci using double-stranded DNA cytidine deaminases. 1/4 https://t.co/82sYsnmwnA

[Brian Liau @brian_b_liau]

Excited to share our latest work, where we develop TDAC-seq to simultaneously map CRISPR-induced genetic variants & chromatin accessibility at targeted genomic loci by leveraging a dsDNA cytidine deaminase, DddA. Highlights below: 1/11
https://t.co/iNyb9ywVzi