Steve Rio

Co-Founder Enfold, focused on consciousness, #5meodmt, Buddhism, mindfulness and taking a somatic approach to healing.

[Bryan Johnson @bryan_johnson]

why I’m at enhances games

[Pinned • Free Peptide Tracker @Pinned_Life]

the 12mg headline is doing the talking but the 4mg line is the real story. 19% loss with fewer dropouts than placebo, one escalation step.

most of the response curve gets captured early. the max dose is for the last few points, not the first thirty.

efficient dose beats max dose. you just have to track to find where yours is!

[Peter Corbett @corbett3000]

@bryan_johnson If every overweight and obese American lost 30% of their body weight it would save $1.2T a year and the fat lost would fill every NFL stadium in the country 100ft deep. 41 TWh of energy in fat. Could power NYC for a year.

[Paul F. Austin @PaulAustin3w]

HHS just made it official:

SSRIs are no longer the federal default, and clinicians now get reimbursed for safely tapering patients off them.

17% of American adults are on these drugs. Most were never told what coming off looks like.

As the grip loosens, the door to psychedelics opens wider.

https://t.co/coZj7FIU9x

[Steve Rio @SteveRio]

I’m on Substack! You’ll find me there thinking about what it means to live a good life, psychedelics, psychology, spirituality, and probably some strength training and peptide content to balance it all out .. join me!

https://t.co/ZQofAxklPG

[Marie Isabella @MarieIsabellaB]

“I’m not mad, just disappointed”

[Steve Rio @SteveRio]

I appreciate @PaulAustin3w doing a detailed follow-up to his original reaction to @bryan_johnson 's livestream. We're aligned on the fact that there are massive gaps in safety and best practices when it comes to 5-MeO-DMT. We're lucky to have voices like Paul's in the mix.

[Paul F. Austin @PaulAustin3w]

My post about Bryan Johnson's 27mg 5-MeO-DMT livestream went viral last week.

I pointed out that 27mg is massive relative to clinical research and that the broader facilitation landscape has a safety problem.

I stand by that. But I've since learned something that added critical nuance to the picture.

The Enfold Institute just published the protocol behind how that session was actually delivered. It's called the Leckie Protocol, and it's far more sophisticated than I realized.

It's a dual-route method that combines intramuscular injection with vaporized inhalation in sequence. The IM dose goes first, followed immediately by the vaporized dose. Vaporization hits in seconds but metabolizes fast, while IM takes 3 to 5 minutes to onset and sustains for 30 to 45 minutes.

By layering both, you get the full somatic release and ego dissolution from the vapor while the IM extends the session into a sustained therapeutic window that neither route can produce on its own.

The dosing is also more precise than a single number suggests. The vaporized component typically ranges from 10 to 18mg freebase, and the IM component from 6 to 9mg freebase equivalent.

These aren't guesses.

They're calibrated individually based on a low-dose introductory session the day before, where facilitators observe each person's baseline sensitivity in real time.

Body mass alone is not a reliable predictor with this molecule, meaning direct observation matters.

This changes the picture for me: what looked like a reckless dose on a livestream was actually a carefully sequenced administration built on 650+ sessions of clinical observation. I could have done more homework before posting.

My core point still holds. Most people sitting with 5-MeO facilitators don't have access to anything close to this level of rigor, and that gap is exactly the problem.

But credit where it's due. The protocol itself is serious work.

What standards should the field adopt to close that gap?

[Steve Rio @SteveRio]

@PaulAustin3w Thank you for this detailed response @PaulAustin3w .. it shows your level of care for the psychedelic space as a whole. Your original point holds as well — there is a massive safety problem, especially with 5-MeO-DMT. Hopefull, we can collectively we can help fix that 🤍

[Brad @BraddrofliT]

If no one else wants to say it, I will:

Stop calling it a TSA crisis.
It’s not broken. It’s being broken on purpose.

Project 2025, page 159.
This is how control gets sold to the public.

You better vote.

[Mikli @CryptoMikli]

Bryan Johnson reveals 5-MeO-DMT therapy outperformed every longevity protocol he’s tried

"If I compare my experience with 5-MeO to having a better diet, exercising every day, sleeping well, doing sauna, and hyperbaric oxygen therapy, this was more efficacious than all of them in terms of a reset of me as a human. It’s just incomparable"

"When you sleep well you feel great, when you exercise you feel great, but nothing compares to what 5-MeO did in terms of resetting me as a human"

[The All-In Podcast @theallinpod]

🚨INTERVIEW: Bryan Johnson just took the world's biggest dose of psychedelics... here are his reactions 48 hours later.

@friedberg sits down with @bryan_johnson

(0:00) Friedberg intros Bryan Johnson

(0:54) Why Bryan Johnson did 5-MeO-DMT

(12:56) What brain scans actually show

(18:36) Psychosis, bad trips, and life-altering decisions

(26:23) The next frontier: organoids and gene therapy

(33:26) GLP-1s, abundance, and human optimization

(35:35) The longevity drug nobody's talking about?

--------------------------------------

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[Steve Rio @SteveRio]

@PaulAustin3w 100%

[Steve Rio @SteveRio]

@PaulAustin3w I'm curious @PaulAustin3w .. do you think that "6.4% reported post-acute difficulties lasting more than a day" indicates that the intervention "went wrong"? IMO, with the proper support, post-acute difficulties ARE part of what creates benficial outcomes. Thx!

[Steve Rio @SteveRio]

@5matthewdub @PhaentGames Ya, it's complicated and there were a lot of details.. I thought he did a solid job overall with harm reduction. It's like someone getting to fly an F-15 and describing the horsepower of the engines incorrectly because you don't understand jet propulsion dynamics.

[Steve Rio @SteveRio]

@PaulAustin3w Appreciate you Paul!

[Steve Rio @SteveRio]

@PaulAustin3w I forgot to mention.. the other factor overlooked is that the IM substance m is a succinate form of 5-meo. This means that up to 35% of the material weight is succinic acid molecule.

[Steve Rio @SteveRio]

@PaulAustin3w Hey Paul! I get your stance here and agree in theory but the math is wrong. There are a number of points people don’t understand about the protocol that Bryan was given.

[Bryan Johnson @bryan_johnson]

This was the most profound experience of my life. I am stunned beyond comprehension. This molecule is without peer.

The 27mg dose opened up what felt like pure consciousness and intelligence. A majestic reveal of existence itself. In all its incomprehensible glory and majesty. It is impossible to explain with words. Whatever you imagine, multiply it by 1,000 and then add infinite width and depth and dimensions.

But entrance was not granted without prerequisite. Existence demanded that I submit. That I say yes; without attachment and without condition. Yes to existence; yes to the dissolution of self; yes to release control; yes, to all.

My ego registered the ask and panicked. It wanted control. It was desperate for control. It pleaded to escape from the torrent of light and essence that threatened to rip my sanity into chards. The urge to eject was overwhelming. Terror thundered throughout my mind and body.

It took everything within me to release. I overcame and was treated with bliss that defies imagination. A euphoria colored with perfect harmony of all things. An orchestra of essence washed over me and swept me up in dance. It was home. The highest aspiration of intelligent life. For some reason, stored and tucked away as the ultimate prize.

A single concept emerged in omnipresence: we cannot grok the preciousness of our existence. Yet it is everything we’ve ever wanted and more. The state we long for without knowing it exists. This caused me great pain and heartache.

A swell of loyalty and devotion emerged inside me, pledging allegiance to existence. To become a warrior and caretaker of life on earth. To protect at any cost the candle of consciousness that has miraculously emerged in this part of the galaxy.

What awaits will wipe all your tears, soothe all your sorrows, and infinitely exceed your wants.

[Steve Rio @SteveRio]

@PaulAustin3w Always love your voice in this space Paul. You’ve been instrumental in educating and raising awareness.

[Steve Rio @SteveRio]

@PaulAustin3w I say this being someone who has administered more doses than all the clinical trials combined. I do this work with an incredible level of care and sophistication.