Viktorija

PhD student @GossGroup St Andrews ⚗️ Organic Chemistry and Synthetic Biology 🧬

[Goss Group @GossGroup]

#NaturalProducts remain a matchless starting point for #DrugDiscovery; made by biomolecules they are predisposed to interact with biomolecules. A privilege to be in this team, led by @marnixmedema , looking at the use of #AI to accelerate NP DD.
https://t.co/V8RIly9dsJ

[Goss Group @GossGroup]

Fully #aqueous .
In #air
Broad substrate scope
#alkylhalide #crosscoupling
Congratulations to Sam Molyneux ⁦@univofstandrews⁩ ⁦@StAndrewsChem⁩

On developing another really useful tool for #GenoChemetics and precision molecular editing

https://t.co/9obahqs9Mp

[Phil Knutson, PhD ⌬ @Phil_Knutson]

I drew a very full glass of wine filled with molecules found in wine! #ChemTwitter #SciArt

[drug hunter @drughunter_com]

Molecule of the Day: Curcumin | https://t.co/EjvA93sQwi

Curcumin is a component of tumeric, and is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.

The molecule is one of the most widely studied therapeutics in history, with papers, reviews, patents, and other sources citing its potential for treating cancer, Alzheimer's disease, hangovers, erectile dysfunction, baldness, infertility, fertility, and any other ailment you can think of.

Curcumin is described as a PAINS molecule, or a "Powerfully Active Ingredient kNown to Scientists." Its biological activities are indisputable - in vitro, it covalently labels proteins, chelates metals, does "the redox," aggregates proteins of all shapes and sizes, makes assay plates glow in the dark, disrupts membranes, and more.

There are over 1000 analogs of curcumin published across 9000 publications and 500 patents, with almost 50 new manuscripts related to curcuminoids published weekly. Federal funds exceeding $150 million have been awarded for projects linked to the study of curcumin in medicine. With >120 clinical trials having been listed for curcumin, this represents remarkably efficient government spending at $1.25M per clinical candidate, far below costs projected by industry.

Remarkably, the molecule is able to achieve all of its in vivo effects with 'abysmal' T1/2 <5 min and oral bioavailability < 1%. As Paul Erlich famously said on his deathbed, "PK/PD is for ninnies."

Curcumin was selected today over ivermectin because innocent people may take this seriously.

[Goss Group @GossGroup]

Outstanding and illuminating seminar ⁦@StAndrewsChem⁩ ⁦@univofstandrews⁩ by a previous ⁦@ChemSocRev⁩ chair, Professor David Parker FRS from @DurhamChemistry.
Powerful development and use of EuroTracker dyes for organelle imaging.

[EPAA @EPAA3Rs]

Read about @EU_Commission commitment to developing a roadmap towards the complete replacement of #animaltesting under the EU’s #chemicals framework at the last #EPAA3Rs Annual Conference in the article by @EURACTIV

https://t.co/oPqyo82xUN

#alternativestoanimaltesting #3Rs

[Iain Smellie @iain_smellie]

@OChemistree We have a colour changing #Chemistree in the @StAndrewsChem teaching lab this year. Theme is organic chem/2022 Nobel prize. Flasks containing glucose, methylene blue and thionin. The big flask contains cream of tartar, copper sulfate and a bit of peroxide. 1/2

[X-Genix @x_genix]

Unbelievable!!
X-Genix ⁦@univofstandrews⁩ is so grateful to have won ⁦@ConvergeC⁩ 2022!!!!!
Thank you so much ⁦@ConvergeC⁩ and thank-you for the amazing support from ⁦@Investing_Women⁩ ⁦@ScotEntNews⁩ ⁦@ERC_Research⁩ ⁦@royalsociety⁩ et al

[Converge @ConvergeC]

How about that! Rebecca Goss @univofstandrews is this year's overall #ConvergeChallenge winner scooping over £69k for @x_genix - a future spinout set to revolutionise global #DrugDevelopment #ConvergeAwards

[Rebecca @RebeccaJMGoss]

Thank you @CEFIC for the fabulous book celebrating #sustainable #chemistry solutions+next generations of chemists.

An honour and privilege to be included in this project, alongside brilliant chemists from across Europe, and to represent #Scotland, @UnivofStAndrews and @X_Genix

[Stuart Conway @conway_group]

It was an honour to serve as the @RoySocChem Organic Division President. Thanks to the Council members and RSC staff for all their help and support. I was grateful to receive this shiny memento a couple of weeks ago. I wish David O’Hagan every success as he picks up the baton!

[Goss Group @GossGroup]

Calling all @UnivofStAndrews students

Interested in helping toward resolving the #energy crisis?
Passionate about #sustainability?

We are delighted to be hosting Director General of @CEFIC
Meet Marco Mensink at Student Association 09.00 Wed 26th.

Please RT and post on other SM

[Rebecca @RebeccaJMGoss]

Amazing few days in stunning #SanFrancisco meeting old friends and new, immersed in amazing science, beautiful art and smart business!!
Thank you ⁦@jgi⁩ ⁦@NigelJMouncey⁩ ⁦@ProfArno⁩ ⁦@GoldenSeeds⁩ and the amazing Una Ryan

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[X-Genix @x_genix]

X-Genix are thrilled to be in the finals of @ConvergeC showcasing our technology that enables precision molecular editing.

[X-Genix @x_genix]

Super excited to showcase our X-Genix technologies for precision molecular engineering (alongside awesome companies from across Europe)@RoySocChem 's 10th Emerging Technologies final.
Great platform for meeting with investors and companies.

[Rebecca @RebeccaJMGoss]

Delighted and overwhelmed to receive the prestigious Corday Morgan Prize @RoyalSocChem #RSCPrizes

https://t.co/ZQoyBuW8EY for pioneering the use of enzymatic halogenation/cross-coupling in C-H activation

Super grateful to our amazing team @univofstandrews colleagues &amp; funders

[Cefic @Cefic]

📢📷We celebrate the power of #science &amp; chemical #innovation: more than 30 Europe’s top #chemistry professors, including 2 #NobelPrize laureates &amp; 21 PhD students from all across the #EU gathered in #Brussels to recreate the iconic 1927 #Solvay picture. 👇https://t.co/7y5OJAoTnE

[Goss Group @GossGroup]

Fun team build on West Sands @univofstandrews From blindfolded sandcastle building competitions to sub team tug of war!
But for formal group photos, there's always one that looks in the wrong direction @RebeccaJMGoss ;-) and for you + those missing ...photoshop

[Rebecca @RebeccaJMGoss]

So blessed to have such brilliant female scientists in @GossGroup @univofstandrews @stikonaite, @SFerrinho @DrRoseLynch @HannahLawtherr @MontellaSG Anouk, Adina, @yingzhang Prabs, and Helen, alongside fantastic men!
Happy #InternationalDayofWomenandGirlsinScience #IDWGS2022