The STRATOS initiative

STRengthening Analytical Thinking for Observational Studies – providing accessible and accurate guidance in the design and analysis of observational studies

[Georg Heinze @Georg__Heinze]

Happy to present this NEW PAPER of the @stratosinit on 'Regression without regrets: Initial data analysis is a prerequisite for multivariable regression'

https://t.co/wdeWBtYrb6

@f2harrell @MHuebnerPhD #stratosida

[Anne-Laure Boulesteix @BoulesteixLaure]

Happy to be part of this huge project by TG9 of @stratosinit led by J. Rahnenführer, L McShane and @RiccardoDeBin1, with @StefanMichiels @LaraLusa and others

[Maarten van Smeden @MaartenvSmeden]

NEW PAPER
Simulation study comparing elastic net vs PCA/PLS for developing clinical prediction models
https://t.co/M7ysE2n9aZ

[BMC Medicine @BMCMedicine]

NEW Guideline article from Jörg Rahnenführer et al. as part of @stratosinit: Statistical analysis of high-dimensional biomedical data: an introduction to analytical goals, common approaches and challenges
https://t.co/WibmCoy2Y4

[Maarten van Smeden @MaartenvSmeden]

People often ask what it takes to develop a successful (clinical) prediction model

Here are TEN important things to avoid

[Didier Brassard, PhD @didier_dtp]

New @stratosinit article: "Issues in Implementing Regression Calibration Analyses" https://t.co/tPWuM69TMj

[Anne-Laure Boulesteix @BoulesteixLaure]

A replication crisis in methodological computational/statistical research ?

I have now been working on the topic for 13 years with my group and it is time for a (long) thread.
First, let me say this is not about the replication crisis in application fields of statistics.
1/n

[Maarten van Smeden @MaartenvSmeden]

@WvanAmsterdam This by @DrPerpo may interest you @stratosinit https://t.co/sqtnTnOZNc

[David McLernon @davemclernon]

1/ New STRATOS @stratosinit article:

Are you validating a prediction model developed using Cox proportional hazards?

Some key points from our new guidance paper 👇

Ann of Intern Med: https://t.co/yTXqJAoUz8
Preprint: https://t.co/lEoLSl1C1S

[Maarten van Smeden @MaartenvSmeden]

NEW PAPER
Overview of performance measures for time to event prediction models. Comes with elaborate R and SAS code

Journal version (paywall) 👉 https://t.co/pb4soc8Cvi
Preprint 👉 https://t.co/0agyWyGAXB

[Maarten van Smeden @MaartenvSmeden]

#8: Dealing with competing risks when validating a prediction model can be challenging. This paper on behalf of @stratosinit gives guidance and R code

Open access 👉 https://t.co/7Qu8qFRBue

[Anne-Laure Boulesteix @BoulesteixLaure]

Edwin Kipruto and Willi Sauerbrei published the **protocol of their methodological comparison study** (simulation study) in PLOS ONE. Great initiative, very inspiring for our community!
https://t.co/jxtUR6LAbD
They follow the ADEMP scheme by @tmorris_mrc

[I.H.Tanboga, MD, PhD @ihtanboga]

@SolomonKurz I would use spline or fractional polynomials. Excellent review by @stratosinit @f2harrell @Georg__Heinze

https://t.co/LoVRIXSaYo

[RVVieira @RuteVVieira]

And 2nd day of #RSS2022Conf begins with STRATOS guidance for survival, competing risk and dynamic risk prediction models @RSSMedSection

[Suzie Cro @Suzie_cro]

Are randomised trials answering clear & useful questions? We conducted this review of published trials to find out https://t.co/ZO2GacCZ90 @bmj_latest

[Georg Heinze @Georg__Heinze]

Perfect summary! 👏thank you @stratosinit

[The STRATOS initiative @stratosinit]

Do you remember when you joined Twitter? I do! #MyTwitterAnniversary

[Stephen John Senn @stephensenn]

“Exposure to guidelines for observational studies can induce altitude sickness, or stratos fear.” Sayings of Confuseus ⁦@stratosinit⁩ https://t.co/a6PI3ThFtL.

[The STRATOS initiative @stratosinit]

The highlight of my year 😍

[The STRATOS initiative @stratosinit]

ISCB has started with a large presence of STRATOS members. If you are at ISCB make sure you drop by on Thursday at the special STRATOS session