Matt Wilson

[Matt Wilson @stringerbell99]

@OrigenNat @Moveandstretch This is partially true, but most oxidation happens in the sub endothelial space after retention. One of the primary ways to reduce retention is reducing the number of particles in circulation. High ApoB also increases ROS, so it increases oxidation in two different ways.

[Matt Wilson @stringerbell99]

It takes less than 5% of your daily cholesterol production to make all of your hormones. Vitamin D is made from a cholesterol precursor made in skin cells, not from mature cholesterol carried in LDL. Part of the “self regulating system” is LDL clearance. If you eat high saturated fat and low soluble fiber, you disrupt that system and increase your LDL.

[Matt Wilson @stringerbell99]

@Moveandstretch And yet all of those things still work optimally with very low LDL. You need cholesterol yes, but this is not an argument for high LDL.

[Matt Wilson @stringerbell99]

@GeoDev1962 @LiveAncestral Do you honestly believe eating cake is the same as eating fruits, grains, and vegetables?

[Matt Wilson @stringerbell99]

@Backto198433421 @QuantumOverlord @LiveAncestral You don’t seem to understand the argument.

[Matt Wilson @stringerbell99]

@KDR_2023 @LiveAncestral Yes that's true, but all of that still happens with very low LDL. Cholesterol can be made in every cell. You don't need a bunch of excess floating around in lipoproteins in your arteries.

[Matt Wilson @stringerbell99]

@LLicit_Tweet @Lunatic__Fringe @LiveAncestral There's a mountain of evidence that proves him wrong, but he will stick with it no matter what.

[Matt Wilson @stringerbell99]

@crnvr_invictus @LiveAncestral Your body will make all you need. There’s no dietary requirement for cholesterol.

[Matt Wilson @stringerbell99]

The human body makes lots of things that are beneficial at normal levels and dangerous at higher levels.

Almost every cell in your body can make its own cholesterol. Your brain has to because LDL doesn’t cross the blood brain barrier.

It takes less than 5% of your daily cholesterol production to make all of your hormones. Vitamin d is made from a cholesterol precursor that’s made in skin cells. It doesn’t come from LDL.

Cholesterol is not the enemy. The lipoproteins needed to carry it in the blood are what gets damaged and leads to atherosclerosis. Keep your ApoB low and cholesterol performs all of its beneficial functions without raising your risk of CVD.

[Matt Wilson @stringerbell99]

@AncientGforce @AmmousMD It’s maybe 20%, but your brain makes all of its own cholesterol anyway. It doesn’t get it from your blood.

[Matt Wilson @stringerbell99]

@LiveAncestral The irony… @grok what are the primary sources of AGEs for non diabetics?

[Matt Wilson @stringerbell99]

For non diabetics, the primary source of advanced glycation end products is dietary. The largest sources of dietary AGEs are proteins and fats cooked at high heat. If you think you’re avoiding glycation by not eating sugar, you’re misinformed, especially if you’re eating a lot of grilled meat.

[Matt Wilson @stringerbell99]

@VigilantFox @P_McCulloughMD He’d have a lot better credibility if he just quit talking after Covid. Now every time he opens his mouth he says something dumb that’s easily disproven.

[Matt Wilson @stringerbell99]

@Gearoidmuar @LiveAncestral I’m not. I’m going on the best evidence we have - large observational studies as well as mechanistic studies, like those showing butyrate stops the proliferation of cancer cells and induces apoptosis.

[Matt Wilson @stringerbell99]

@slayerment @Tellit007 @LiveAncestral The post doesn't even mention CVD. Did you read the post?

[Matt Wilson @stringerbell99]

@Gearoidmuar @LiveAncestral All short term and on people who already had cancer or polyps.

[Matt Wilson @stringerbell99]

Yes the fact they had trouble finding people who met their metabolic criteria is interesting in its own right. I think metabolic health is a very important factor, but so is apob. People with genetically low lifetime ApoB have greatly reduced CVD regardless of their metabolic health.

Poor metabolic health (and other factors that degrade endothelial function) expose more transport receptors that move ApoB into the sub endothelial space. Higher ApoB moves more particles through the transport receptors that do exist. Both lead to more retention and oxidation which leads to plaque.

[Matt Wilson @stringerbell99]

@TheCuriousCorv @KayBwt @Tellit007 What evidence do you base this on? The keto CTA trial set out to prove this exact idea and instead 85 out of 100 participants added plaque in one year.

[Matt Wilson @stringerbell99]

@Fod64959943 @BarbaraOneillAU 🙄

[Matt Wilson @stringerbell99]

That's like saying "calcium causes kidney stones". It's not an accurate framing. Most people = healthy people without medical conditions that make them more susceptible to kidney stones. Just type in "do dietary oxalates cause kidney stones in healthy individuals" to your google AI and you can read through all the source material.