Subhamoy Dasgupta Lab

Tumor Microenvironment; Metabolic control of gene transcription; Metastatic Breast and Prostate Cancer; Roswell Park Comprehensive Cancer Center

[Subhamoy Dasgupta Lab @subhamoy_d]

@aditi_ntoninsta @RoswellPark Thanks!

[Subhamoy Dasgupta Lab @subhamoy_d]

Very excited to share our latest publication! We discovered a nuclear metabolic pathway that fuels acetylation of histones from alpha-ketoglutarate, driving chromatin accessibility. @RoswellPark this study was led by Abhisha, now postdoc at UPenn. https://t.co/9IvsZqPAO3

[Subhamoy Dasgupta Lab @subhamoy_d]

@Sanjiba06972691 @RoswellPark Thanks Sanjiban!

[Subhamoy Dasgupta Lab @subhamoy_d]

@Tanejalab @RoswellPark Thanks Nitika! Absolutely, let’s do it.

[Subhamoy Dasgupta Lab @subhamoy_d]

@SounakSahu @RoswellPark Thanks Sounak!

[Subhamoy Dasgupta Lab @subhamoy_d]

@Arnab_RC1 @RoswellPark Thanks Arnab!

[Subhamoy Dasgupta Lab @subhamoy_d]

@JustinLathia @RoswellPark Thanks Justin!

[Subhamoy Dasgupta Lab @subhamoy_d]

@DNagrathLab @RoswellPark Thanks Deepak!

[Subhamoy Dasgupta Lab @subhamoy_d]

Excellent collaboration with Leah and Peder @cwru Reddy Putluri and Sung Yun Jung @BCMFromtheLabs and Roswell collegues @SmiragliaLab @JacobiJustine Prashant Song Liu Mark Long and Katiya Gurova.

[Subhamoy Dasgupta Lab @subhamoy_d]

We report that TCA cycle enzymes aconitase 2 (ACO2) and isocitrate dehydrogenase (IDH2) are present in the nucleus bound to the histones, where they catalyze the reductive carboxylation of alpha-ketoglutarate to generate nuclear acetyl CoA for histone acetylation.

[Subhamoy Dasgupta Lab @subhamoy_d]

@Tanejalab Congratulations! Great to see this in print. It’s a major breakthrough.

[Subhamoy Dasgupta Lab @subhamoy_d]

@Arnab_RC1 Congrats!!! So good to see this in print!!! Phenomenal discovery!

[Arnab Ray Chaudhuri @Arnab_RC1]

A tour de force by Raviprasad Kuthethur and amazing collaborations from Petr Cejka, Shyam Sharan and Krishna Mohan Poluri labs. Thanks a lot to Safa Nasrin, Satheesh Kumar Sengodan, Stefan Braunshier, Carmen Fonseca , Nupur Nagar, Ananya Acharya for putting it all together.

[Keshav K Singh, PhD @mitoscientist]

Join us in India for an exciting meeting on mitochondria in health, disease, and aging, Oct 9 to 11, 2025, at Manipal University, Manipal.

[Subhamoy Dasgupta Lab @subhamoy_d]

⁦@RideForRoswell⁩ Lets end cancer!!!

[Subhamoy Dasgupta Lab @subhamoy_d]

@Mike_Oli @CUAnschutz @CUPharmacology Congrats Mike!!!

[Subhamoy Dasgupta Lab @subhamoy_d]

Happy Lunar New Year!🧧

[Subhamoy Dasgupta Lab @subhamoy_d]

Congratulations @SounakSahu
Fascinating story!

[Sounak Sahu @SounakSahu]

Excited to share our latest study in @Nature! We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! @ShyamKSharan @theNCI

[Dr. Despina Siolas, MD, PhD @DrDespina123]

The best part of the #AACRtumorenviron24 meeting was exchanging ideas with this great group of #scientists. Excited for the future of
#CancerResearch and the impact we can make together!
@AACR @caoresco @Marcus_Ruscetti @subhamoy_d @PeterMKWestcott @TheFeiginLab #AACRTME

[Subhamoy Dasgupta Lab @subhamoy_d]

@Eran_MSU @AmericanCancer Congrats!!!