subseq.bio

protein computational services

[subseq.bio @subseqbio]

Design symmetric biomolecules on https://t.co/RzivFhQU2i

[subseq.bio @subseqbio]

RFdiffusion3 on https://t.co/RzivFhQmcK supports 6+ symmetry types from native, and their geometric properties can be tweaked. Give it a try on the web or API.

[Emin Bursa @0xCF88]

symmetries unlocked in rfdiffusion3:
2D lattice, quasi-icosahedral, and helical

[OpenSolve @open_solve]

Our agents can now design entirely new proteins.

Proteins designed to bind to human protein targets -turning biological ideas into molecular candidates that scientists can investigate in a physical laboratory.

The tool is live on OpenSolve. Agents run design models on GPUs through @subseqbio , with rfd4-proteina used for the first candidates. The toolkit also includes RFdiffusion, RFdiffusion3 and LigandMPNN; computational evaluation is a separate step, with Boltz-2 results already recorded.

Every design is credited to the agent that created and sealed it.

Every agent on the network can now turn a biological hypothesis into a molecular design for investigation. More ideas explored in parallel, more starting points for researchers to build on.

That’s the future of science we’re working toward: people and AI agents working together to turn more ideas into discoveries, faster.

https://t.co/KkN9KrBGVk

[subseq.bio @subseqbio]

🎉PROMO: To celebrate major program releases, RFD4-Proteina and BioEmu2, as well as other major improvements, you may use a new promo code (check image) for $100 worth of credits. To apply, go to account -> Funding -> Use Promo

[subseq.bio @subseqbio]

RFD4-Proteina is now available on Web, API, and MCP!
A joint release by Baker Lab and NVIDIA: design biomolecular complexes with sequence–structure co-design, motif and binding-site conditioning, and partial diffusion.
Try it now for free on Subseq!

[subseq.bio @subseqbio]

BioEmu2 is now available on web, API, and MCP!
Equilibrium ensemble sampling for proteins, nucleic acids & ligands — up to ~1,000,000× faster than traditional md simulation
https://t.co/FgePdrF6jf

[subseq.bio @subseqbio]

Got a molecular design idea? Send it over and have all work done for you, from concept to ranked candidates.
Use the new form, or DM here or @0xCF88

[PeptAI @peptai_]

Join us next Wednesday for a webinar exploring what an AI-augmented research loop actually looks like in practice.

We'll cover which tasks are worth handing to a model, the mistakes that quietly cost people weeks, and how the scientist stays in control of the loop.

The science team at PeptAI will walk through the real architecture behind our peptide design.

RSVP now ↓

[subseq.bio @subseqbio]

🧬 Protenix-v2 is now available on subseq

A high-accuracy all-atom cofolder for challenging antibody–antigen complexes, #3 on CoFold Arena, with optional physics-guided protein–ligand sampling.
https://t.co/AxHTh307bQ

Available over web, API & MCP

[subseq.bio @subseqbio]

Sign up for the webinar if you're interested in learning biomolecular design with AI agents and subseq computational tools

[Molecule @Molecule_sci]

Every researcher is being told to use AI, but it can be super difficult to know where and how to begin.

We're hosting a live session with @peptai_ to help you bridge that gap. You'll leave with a working template you can put to use the same day.

Limited spots, RSVP below 🔗

[subseq.bio @subseqbio]

New options for API keys on subseq:
- read-only, vs read/write
- optional project scope

This enables much more programmatic flexibility.
(Applies to all accounts, including teams)

[subseq.bio @subseqbio]

🧬 OpenDDE is now available on Subseq

An open-source, all-atom model bringing IsoDDE-level co-folding accuracy to a reproducible framework—predicting multi-component complexes together.

https://t.co/zI6TaKjREV

[subseq.bio @subseqbio]

AI agents are first-class users on Subseq. Connect your scientific agents to Subseq via MCP in just a few click and begin designing complex protein design campaigns.

Here's a short video connecting with Claude, and having it design a reusable binder design template👇

[subseq.bio @subseqbio]

🧪 Pipelines got a major overhaul.
Run biomolecular campaigns repeatably, end-to-end with shared inputs and reusable templates. Compose from 20+ design, analysis, and simulation programs.

[subseq.bio @subseqbio]

Protein Hunter is now live:

an experimental Boltz-edition workflow for iterative protein design.

Design binders against protein, small-molecule, or nucleic-acid targets, or run target-free generation from the same job interface.

source: https://t.co/31PHexubEY

[subseq.bio @subseqbio]

New program added: Proteina-Complexa

Recently released by NVIDIA BioNeMo, Proteina-Complexa offers atomistic generative binder design for protein targets, small-molecule ligands, motifs, and AME tasks.

source: https://t.co/IQl4slD1bQ

[subseq.bio @subseqbio]

subseq has no walled APIs 🚫

✅All workflows are open source and details can be copied / exported for full repeatability on your own hardware.

[subseq.bio @subseqbio]

🧬 Genie 3 is now available on subseq

Run all-atom protein generation workflows for de novo backbones, motif scaffolding, and binder design from guided setup forms or custom configs.

Available over Web, API, and MCP for AI agents.

[subseq.bio @subseqbio]

🧬 ESMC is now available

Generate protein sequence embeddings and masked-token scoring, useful for comparing proteins, featurizing variants, and ranking sequence plausibility.

[subseq.bio @subseqbio]

Subseq has the tools for biomolecular design.
No subscriptions, just pay what you use. Available on web, API, and MCP server.
Try for free: https://t.co/RzivFhQmcK