Histopathologic Flavors of Metastatic Prostate Carcinoma - Undifferentiated
🔷 High-grade carcinoma
🔷 Typically NKX3.1/AR negative. Neuroendocrine markers can be spotty/nonspecific.
NGS can be helpful in reaching the diagnosis of prostate origin.
Dr. Chan #USCAP2026 #pathology #PathX #PathTwitter
@Pathology36@DrGeeONE@Histopatolomon@glucerorg@pathologysocial I am doing fine, just a busy bee in a field of all kinds florishing pathology flowers, picking the nectar from them. Good to hear you are doing great. Applying fellowship? in what field? I use this beautiful Poroma to welcome you back #dermpath🥰
9/ FOPD should have the following histological features:
⭕️Vague zonal architecture
🟣Nodules of plump fibroblasts and myofibroblasts (SMA positive)
🦴Osteoid rimed by benign osteoblasts
💦Myxoid matrix
❌🥴No atypical mitosis or malignant cytology
https://t.co/NJhuJ6h26D
Lung - Lepidic pattern and micropapillary pattern can show as a ground glass lesion on imaging
That is why our job is to recognize the micropapillary pattern which is commonly missed (considered high grade, and any tumor with >20% of high grade component is considered poorly differentiated)
Even 5% of micropapillary or solid pattern is associated with worse outcomes
Classic micropapillary pattern (Pic 1)
Not so classic presentations of micropapillary pattern (pic 2)
Dr. Butt #JobPrepBootcamp #NIPCAP #pathology #PathX
⚠️PITFAAL ALERT ⚠️
FROM: Who Cheal Cho MD:
Fat atrophy, often associated with severe malnutrition, can histologically mimic other malignant conditions, particularly SIGNET RING CELL CARCINOMA. This is an example of starvation-induced fat atrophy in the omentum.
Happy and honored to see our @Pathoutlines article on Acral Fibrochondromyxoid Tumor published online!
👉🏻https://t.co/j8e4gCn1x4
Here's three things to remember about this benign tumor:
▶️Well circumscribed w/ lobules separated by fibrous septa with numerous slit-like blood vessels & hyalinization at the septal periphery
▶️Cells look myoepithelial-like in a fibrochondromyxoid stroma, but are panCK & SOX10/S100 negative!
▶️Partial cartilaginous differentiation: consistently CD34+, ERG+ (and in 70% of cases also SOX9).
💎Bonus: it harbors a recurrent THBS1::ADGRF5 fusion.
Check out the full PathOut article using the link above!
#BSTPath #PathTwitter
Extraskeletal Myxoid Chondrosarcoma (EMC) is a rare tumor with an estimated incidence of <3% among of all soft-tissue sarcomas. It is characterized by a multinodular architecture, abundant myxoid matrix, and malignant chondroblast-like cells arranged in cords. (1/3).
#BSTPath
___ favor chondrosarcoma (over enchondroma)
A) myxoid degeneration
B) erosion & entrapment of bone
C) tendency for axial skeleton
D) all of the above
🖼️🙏Dr Roberto Garcia PathCast https://t.co/i09zVcvqvj
#BSTPath#PathResidents#PathTwitter