Sebastian von Huth

MD👨‍⚕️PhD👨‍🔬 @OUHhospital, Denmark 🇩🇰 - Dept. of Infectious Diseases. Specialist in #infectiousdiseases 🦠💉

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🔥State of art review article by 🌟 s
@DrToddLee @syctong
Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management
"Further subgroup analyses from SNAP will clarify whether the CzIE differentially impacts outcomes with cefazolin versus ASPs. In the meantime, cefazolin should be broadly considered the preferred treatment for most MSSA bacteremia"
Thanks @Inox94 #IDXposts
https://t.co/kuOb4aE9tD

[Paul Sax @PaulSaxMD]

Three antibiotic myths that simply refuse to die — penicillin allergies, the “must finish every dose” rule, and the idea that antibiotics help colds.

New post -- link on next tweet👇

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Just published
The GAME CHANGER RCT
Among patients with a hospital-acquired or health-care-associated Gram-negative bloodstream infection, cefiderocol resulted in non-inferior but not superior 14-day mortality compared with standard of care #IDXposts https://t.co/jLWmphItGK

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🔥Prospective,multinational PK study by 🌟 @jasonroberts_pk
Meropenem & pip/tazo optimised dosing regimens for critically ill patients receiving RRT
Dosing nomograms developed to inform dosing for different RRT settings, urine outputs & target conc
https://t.co/XgC0GuPaYz

[Timothy Li @drtimothyli]

Timeline of chikungunya fever

Typical viral load, symptoms, involved immune cells, and antibody titres during different phases of disease are depicted

https://t.co/pF74oFG6pv

[Brad Spellberg @BradSpellberg]

Hi @iPhoOzZ, I just sent you a detailed email response. Thank you for asking this very important question, which affords me the opportunity to offer one of my trademark antibiotic rants. Oooh, feels good, haven't done one of these in a while! Ok...strap in, here we go...

[Sebastian von Huth @svhuth]

@FSBuchholzer Dr. [full name] at your service 🫡

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal

[Timothy Li @drtimothyli]

Why shorter is better

"It's the same efficacy, but safer and with less selection for resistance."

"If you're going to give antibiotics to people who don't need them, at least do us the courtesy of doing it for a brief period of time."

@BradSpellberg

https://t.co/tIZuqWdBqK

[Ross Prager @ross_prager]

Night shifts are associated with a higher risk of death ☠️👇

Here are some evidence based approaches to maintaining healthy while working shifts. A 🧵
(1/x)

[Jasmine Sethi @JasmineNephro]

🆕 Hypertension Classification

New AHA 2024 guidelines have omitted

❌Hypertensive urgency

❌Hypertensive crisis

[Timothy Li @drtimothyli]

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis

➡️Standard of care since the 1990s and is currently recommended by several major GI societies
➡️Weak supporting evidence
➡️No clear mortality benefit

https://t.co/MTTlbofjdk

[Luke Turner 🦠 @MicroLukas]

HIV+ & brain lesion?
🧠 Toxo – #1 cause, multiple ring-enhancing lesions
🦠 TB – Tuberculoma, may mimic tumors
🍄 Crypto – Often with meningitis
🧬 PML – JC virus, non-enhancing white matter lesions
🐛 Neurocysticercosis – Cysts, endemic areas
🧫 Abscess (Nocardia, etc.)

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

2024 was a 🔥 year in ID
🆕💫 @CIDJournal @VUMC_ID @JeffFreiberg
What’s Hot This Year in ID Clinical Science
The review highlights some of the most important trials and clinical trends in infectious diseases over the past year #idxposts https://t.co/JqFrv1iSKS

[Sebastian von Huth @svhuth]

Excellent review on antibiotic duration for various common bacterial infections - again proving that in most cases, #shorterisbetter

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💫 Systematic review @jac_amr
Antibiotic duration for common bacterial infections
Out of 315 studies, 85% concluded equivalence or non-inferiority of shorter courses
Non-inferiority was the most commonly adopted design @BradSpellberg #idxposts https://t.co/JnskIx3WgZ

[Luke Turner 🦠 @MicroLukas]

A potentially useful table for anyone interested in understanding the recommended usage of some of the newer antibacterials, e.g. latest beta-lactam/inhibitor combinations.

#AMR #AMS

[Luke Turner 🦠 @MicroLukas]

Flu season is here! 🌡️

A quick thread on understanding the basics (and dangers) of influenza (flu)

[Sebastian von Huth @svhuth]

@larsfolkestad @EmpiricGame Ho ho ho 🎄

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥🔥 NEW 🔥🔥
Year In Review: Top Infectious Diseases Articles From 2024
Our new post, a great collaboration with my friend
🌟 @IDstewardship
1️⃣6️⃣⚡️🆔 RCTs
@JAMA_current @TheLancet ✨
7️⃣Syst Reviews/Meta
3️⃣🌏Guidelines
@Wiki_Guidelines ✨️
#idxposts
https://t.co/8YWtXqoyrx

[Brad Spellberg @BradSpellberg]

A brief tweetorial. The belief that IV is more effective than oral Abx is incorrect. No data to support it. Contrary data to refute it. And it makes no logical sense. The bugs can't know how the abx got there. They only know if enough gets there to inhibit their growth...