Using the marks on ancient coinage, one can figure out the number of dies used to produce them and estimate the total volume of coins minted.
I have plotted below the total amount of coinage produced in the ancient world from the emergence of coinage to the end of the Roman Republic.
Several large surges of coin production can be seen on the graph:
Post-330 BC Alexander the Great conquered Persia and used the massive hoards of silver and gold found in the royal treasuries to issue vast quantities of coinage to pay his troops.
During the Second Punic War (218–201 BC) the Romans made emergency issues of vast quantities of silver denarii to fund the war effort. Another such surge occurred in the 80s BC during the Roman Social War and subsequent civil wars.
Who knew, in Tin Tin there is a cigarette brand called "Macedonia" or to be more correct they are "zigarettes" and the brand in cyrillic is called "mazedonia"