Johan Lundberg

Head of MRI at Dept. of Neuroradiology at Karolinska University Hospital in Solna and researcher at Karolinska Institutet.

[Johan Lundberg @SWICU_Rays]

Might RAAS imbalance contribute to COVID-19? I would like to share our paper raising some interesting questions. https://t.co/NsT3941QHh
I would also like to thank my awesome co-authors @ryszsus @JonathanSaadi and @FagerlundMalin What's the paper about then? (Thread)

[JIM - Journal of Internal Medicine @JInternMed]

New research from @karolinskainst: Lung perfusion disturbances in non-hospitalized post-COVID with dyspnea.

🆓https://t.co/gpyUefDtwI

#postcovid #covid19

[Johan Lundberg @SWICU_Rays]

@DoktorZjivago Men om vi inte trodde det var solitt skulle vi inte skriva manus.

[Johan Lundberg @SWICU_Rays]

@DoktorZjivago Cave: preprint också.

[Johan Lundberg @SWICU_Rays]

Finally, I want to thank my AWESOME co-authors for all the hard work behind the manuscript!

[Johan Lundberg @SWICU_Rays]

I want to share a pre-print detailing findings in a prospective convenience sample of people suffering from dyspnea post-COVID.
The main findings are that we can detect lung perfusion disturbances by using MRI 4- 13 months after non-hospitalized SARS-CoV-2 infection.

[medRxiv @medrxivpreprint]

Lung Perfusion Disturbances Detected with MRI in Non-Hospitalized Post-COVID-19 Individuals with Dyspnea 3 -13 Months after the Acute Disease https://t.co/TTaKTPTEIH #medRxiv

[Johan Lundberg @SWICU_Rays]

This study has some limitations, including a lack of other supporting imaging modalities. CT scans would likely detect morphological lung changes with higher sensitivity, but the current MRI protocol was optimized with advanced morphological imaging, including USE imaging. (7/x)

[Johan Lundberg @SWICU_Rays]

@dronico No! Thank You for the notification! In my humble opinion ACE2 has no effect. It is probable that the shift in ANGII/ANG(1-7) ratio is the effector mechanism after reading only the abstract. Will read the entire paper tonight!

[Johan Lundberg @SWICU_Rays]

@Nephro_Sparks That would be much appreciated! I've read a lot of Your work during the last year. Never heard of You and knew very little about the RAAS before that since I do mostly rays ... I apologize in advance for my ignorance!

[Johan Lundberg @SWICU_Rays]

@Nephro_Sparks But, I agree with You and You are entirely correct! It was a fair critique. What do You think of the paper's actual findings? Not many findings are new compared to ample small animal data. I think that the striking thing is the compounded effect in one animal.

[Johan Lundberg @SWICU_Rays]

@Nephro_Sparks @__philipn__ Thank You for Your feedback. After a year and seven different reviewers, we decided to not update anything outside the scope of the critique. I'm sorry that our decision looks sloppy. It was never our intention.

[Johan Lundberg @SWICU_Rays]

@Nephro_Sparks @__philipn__ Yeah. That would have been nice. @NatureComms ?