After a great opening ceremony, fantastic lecture by Jeffrey Bode, and busy first exhibition session, we're ready to do it all again today at the IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry!
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Some companies recognise the need to adopt new technologies, but it will only happen if there's a willingness to try “something new”. Some technologies might be all hype, but if we don’t try, we’ll never know...
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#drugdiscovery
This review provides a useful overview of C-H bond activation in highly functionalized molecules.
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#C-Hactivation #catalysis
This paper reports on the use of sulfenate anion organocatalysts for the preparation of trans-aziridines.
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#organocatalysis#synthesis#aziridines
Delighted to share our new paper from Digital Discovery on the easy, robust automation of PROTAC synthesis. Check it out if you want to know more about synplifying your PROTAC preparation!
#protacs#digitaldiscovery#medchem
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This paper reports on various new deconstructive functionalisations of cyclic aliphatic amines to achieve skeletal diversification.
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#synthesis#amines
Check out this article, which looks at the impact that the Ro5 has had on medicinal chemistry over the last 25 years and the relevance of this rule today and in the future.
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#Ro5#medchem
Want to know more about optimising chemical reactions? Check out this new review and find out about all the techniques available.
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#reactions#optimisation#synthesis
Delighted to share this new Org. Lett. paper from our work with @bode_lab on the development of a Synple automated process for Suzuki−Miyaura cross couplings!
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#suzuki#synple#labautomation
Hot on the heels of PROTACs, what's next in the field of proximity-inducing drugs? Check out this review for more information!
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#drugdiscovery#medicinalchemistry
Methodologies that accelerate hit discovery are desirable and multicomponent reactions that give rise to some complex, interesting looking scaffolds present a great option for this.
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#medchem#synthesis#drugdiscovery