I launched my lab at @UMassAmherst this fall. We study the mechanisms of meiotic homolog pairing using advanced live‑cell and super‑resolution imaging. Currently in budding yeast, with plans to expand to other eukaryotes. #Chromosome#Meiosis#Mitosis
https://t.co/BPvQghmCx2
(1/16) Our 3-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack is out:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): https://t.co/wyPaLyvR8A
My lab @UTD_Biology is hiring a research technician who studies the mechanisms of nuclear transport and organization using the Drosophila brain as a model system! https://t.co/qlz0dZQZ9f
MEIOSIN retains an intrinsic STRA8-independent activity that drives meiotic entry across vertebrate evolution https://t.co/MPaG4knnHl This paper will be published from Genes Dev
SeeDB-Live is a tissue-clearing approach for live tissue slices or brains, improving image quality while having minimal effects on electrophysiological properties of neurons. @TakeshiImaiLab@Shigenori774
https://t.co/3mzllLyuW4
Our review is now live @TrendsCellBio. We discuss how the DNA repair pathways c-NHEJ, MMEJ, and HR intersect at mammalian telomeres and the consequences for chromosomal instability. https://t.co/TTstou5YZW
Our chromatin dynamics paper is now in @NatureSMB with important updates. We tracked chromatin in additional cell lines (5 overall), from the shortest timescales accessible today, over 6-7 orders of magnitude in time (MINFLUX + camera-based tracking)
https://t.co/nMU4k0V6kS
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵
Link at end!
Geneticist J. Craig Venter, best known for his role in sequencing the human genome, has died aged 79.
He spoke to Nature in 2023 about AI, sequencing the ocean – and why he had no plans to stop working.
https://t.co/FYq5jbMpxa
Today in @Nature, the @genophoria & Vijay Ramani labs reveal that our picture of how nucleosomes regulate DNA accessibility has been too simple. They find that over 85% of nucleosomes in mammalian cells are structurally distorted, with DNA partially accessible even while wrapped.
Excited to share our new paper! Using a tunable frog egg extract system, we show that nucleosome density and histone dynamics actively shape mitotic chromosome architecture. https://t.co/0OVQGxR5cO
Last week's fantastic seminar by Prof. Harmit Malik, "Genetic Conflicts Drive The Unexpected Rapid Evolution Of Essential Chromatin Proteins", can now be viewed on CPGE's YouTube channel!
#chromatin#genomics#evolution#northwestern#genomics#proteins
https://t.co/trFeWYYJiV
My latest perspective on the regulation of DNA replication and 3D genome organization in early mouse embryogenesis, including why four scRepli-seq studies reached slightly different interpretations. https://t.co/9LV2jdbQ0R
I’m tenured! Thank you so much to everyone here, mentors, lab mates, colleagues, and the meiosis/centromere community for your support. This achievement was made possible by all the hard work by my amazing lab members over the past 6 years!🥳
Our Long-Term Benefit Trust has appointed Vas Narasimhan to Anthropic's Board of Directors.
Vas brings more than two decades of experience in medicine and global health, including as CEO of Novartis.
Read more: https://t.co/DSvtZUTone