Ed Tate

A group of chemical biologists at Imperial College London and the Francis Crick Institute

[Imperial Chemistry @impchemistry]

Congratulations to Myricx Bio, a spinout co-founded by @TateScience based on research from @impchemistry & @TheCrick, which has raised £90m to move its novel cancer treatment into clinical development 👏 @RoySocChem #startup #cancer @imperialcollege
https://t.co/N8yV8r1ZcP

[Ed Tate @TateScience]

@merckgroup @dusan_medchem @MargaridaEspad1 @Borodin_O_ @BeatriceLansbe1 @mvdelius @BelgradeUni @uniofeastanglia @UAntwerpen @UofGlasgow @TU_Muenchen @Elena_De_Vita @imperialcollege Many congratulations @Elena_De_Vita & team!

[Ed Tate @TateScience]

Join our group as a Research Associate in Cancer Drug Discovery! See below for more on the medicinal chemistry challenges of designing novel covalent ligand series against traditionally intractable cancer drug targets https://t.co/3zilRwYo8B

[Ed Tate @TateScience]

We're looking for a Technical Specialist in Mass Spectrometry to join the Chemistry Department at Imperial's White City campus. Read about how the role can help us get the most of our state-of-the -art instruments https://t.co/PPqXP9VxDb

[Ed Tate @TateScience]

Apply for a fully funded 4 year PhD studentship researching antibody-drug conjugates (ADCs) in collaboration with AstraZeneca. Shortlisting closes by March 23rd! https://t.co/lwzWlAFvNF

[Ed Tate @TateScience]

Our new research on UV-light activated probes that can discover novel protein-protein interactions in @ChemicalScience https://t.co/wz7C2zdHkG

[Bubeck Lab @BubeckLab]

Funded by @ERC_Research, a new study from the lab out in @NatureComms discovers how a tiny protein called CD59 provides a last line of defence against a giant b-barrel immune pore. https://t.co/ppfMoW8oAf. @EmmaCouves @TomasVoisin @scott_d_gardner @TateScience @pstansfeld

[Ed Tate @TateScience]

Celebrating #internationaldaywomenandgirlsinscience 2023 @TateScience @impchemistry and @TheCrick ! Very proud to work with this amazing group of scientists!

[Ed Tate @TateScience]

Apply now! 2 fully funded 4yr PhD studentships for Oct 2023 - new deubiquitinase (DUB) probes & approaches to discover & drug protein allosteric sites - shorlisting closes mid-Feb!
https://t.co/MFZMazuJzO
@impchemistry @ubiquigent @lwalport @TheCrick @laboratorychild @s_yaliraki

[Ed Tate @TateScience]

Congratulations to @TateScience members Leran, Dan, @Elena_De_Vita, @scottlovell34, @AndreaGoyaG, and the teams of Aubrey Miller @DrugDiscov_DKFZ, Svend Kjaer @TheCrick and Janosch Hennig @embl on their report @J_A_C_S of a potent and selective probe for KLK6!

[J. Am. Chem. Soc. @J_A_C_S]

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion @TateScience @imperialcollege #ActivityBased #PancreaticCancer #Cell #Invasion
https://t.co/GFPHIlde6Y

[Bubeck Lab @BubeckLab]

Computational resources provided by @hecbiosim allowed us to see how the lipid environment could tip the balance between CD59 as an immune regulator or host receptor hijacked by bacterial virulence factors.

[Ed Tate @TateScience]

Excited to announce CORe, proteome-wide in-cell site-directed mutagenesis screening @NatureMicrobiol! Deconvolute role of any ligandable site, reactive amino acid, PTM, and more, at scale, at endogenous abundance! Fantastic collaboration with @laboratorychild @henrybenns

[Nature Microbiology @NatureMicrobiol]

Out now, drug discovery for apicomplexans👉CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery @laboratorychild
@henrybenns
@TateScience
@imperialcollege https://t.co/10yiy8Kqge

[Ed Tate @TateScience]

@DrugDiscov_DKFZ @DocKlahn @StephanHacker2 @LynJonesChemBio @SieberLab https://t.co/5BAqr4mDwo
In Fig 1E we show an example where CuAAC fails on native lysates at a buried site (photocrosslinked alkyne lipid) but suceeds if CuAAC is done under SDS denaturation, suggests disulfides are likely to survive?

[Ed Tate @TateScience]

Fantastic and unique long-term position for synthetic medicinal chemists interested in research supervision, #training, #education and #innovation in #medicinalchemistry and #drugdiscovery. Based in @TateScience @imperialcollege White City Campus. https://t.co/BcxX7Y1zDX

[Ed Tate @TateScience]

Three new positions available @TateScience @imperialcollege and @TheCrick, deadline 9th Nov, start early 2023 - please retweet!

Postdoc positions in cell and chemical biology:
https://t.co/r2OmicB43w
https://t.co/lnPaqJYtmK

Chemical Biology Technician:
https://t.co/TUD2ZaECXr

[Ed Tate @TateScience]

@chembioBryan @UChiChemistry @UChicagoPSD @UChicago @YangCao_awesome Many congratulations Bryan, great news & richly deserved!

[Ed Tate @TateScience]

Fantastic video featuring Anna Barnard https://t.co/Ewl3BRPBDi raising awareness of what we need to do now to stop #AntimicrobialResistance devastating future healthcare, briefly also featuring @Dr_Ravi_Singh
https://t.co/rxXYUKI9Ip

[Ed Tate @TateScience]

Congratulations to @TateScience scientists who created our stand on Innovative Therapies @ExRdFestival 2022! @Elena_De_Vita @Michalska_P_ @ChemGray @Dr_Ravi_Singh Folake Tianze Fangyuan Edward Lame Qisi Haozhe Josephine and more! @WorldwideCancer @impchemistry @TheCrick

[Ed Tate @TateScience]

Many congratulations to @Elena_De_Vita, highly commended finalist in the L'Oreal-UNESCO Rising Talents Life Sciences Award!

[Ed Tate @TateScience]

Apply now! Medicinal chemistry postdoc position @TateScience - join our team @imperialcollege and @TheCrick to work on novel & challenging cancer drug targets, supported by chemical biology and #CryoEM with @OxfordStrubi
#postdoc #postdocposition @CR_UK https://t.co/Y8S8injvtW