Juan Bravo, PhD

Postdoc in the Curran lab at the University of Southern California (USC), studying aging, transposons, and RNA editing. The views expressed here are my own.

[Juan Bravo, PhD @the_TE_guy]

Noted on Bluesky a while back but updating here as well: Happy to share the published version of our last study, where we employed a multi-ancestry GWAS to identify human variants associated with elevated transposon (LINE-1 and Alu) insertion numbers. https://t.co/AWqEyBAmr2

[Peter H. Diamandis, MD @PeterDiamandis]

Russia just committed $26 billion to anti-aging research and made longevity a national priority. Welcome to the longevity arms race!

[Bérénice A. Benayoun, PhD @BBParis1984]

Sharing our new essay, out today at @PLOSBiology: "The problem with one-size-fits-all medicine: Biological sex and the aging immune system", where we argue that personalized medicine must account for #sex.
https://t.co/hpe7fSr2ku

[David J Glass MD @davidjglassMD]

Years in the making: a detailed aging gene signature in mice and rats. >30 tissues, high Ns, multi-time points throughout the lifespan. >5000 samples in total. The data is accessible, so you check to see if your favorite gene is age-regulated.

https://t.co/5heN6ixvt1

[Stephen Turner 🦋 @stephenturner.us @strnr]

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications https://t.co/m9vCAaWguw 🧬🖥️🧪

[Lior Pachter @lpachter]

Ambient RNA & barcode swapping is a serious issue in single-cell genomics. Tools such as CellBender, scAR, DecontX & SoupX. We have developed CellSweep which is faster (in some cases by a lot) and much more accurate. Extensively tested and benchmarked. https://t.co/7ZRjDuJocP 1/

[Profesor Tubio - Mobile Genomes Lab @MobileGenomes]

Jumping 'DNA parasites' linked to early stages of tumor formation https://t.co/oWF6xgcM5R

[Mobile DNA @MobDNAjournal]

Henry L. Levin, Ph.D. has updated his Editor’s Picks for January with standout papers covering topics such as LINE-1 retrotransposons and other advances in genome biology. Take a look 👇
https://t.co/BBBL44Hvvu
📸 Figure adapted from Grinwald MF et al., Trends in Genetics, 2025.

[Ming "Tommy" Tang @tangming2005]

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data https://t.co/uQRXdipF88

[GeroScience @GeroScienceAGE]

🧬 New Research Highlight 🧠

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways by Juan I. Bravo & Bérénice A. Benayoun (@BBParis1984) et al.

This multi‑omics study shows how Alu transposon overexpression in human fibroblasts disrupts key aging‑related pathways, offering deeper insight into genomic instability and cellular aging mechanisms.

🔗 Read the full paper: https://t.co/WkSCenFBBo

[Juan Bravo, PhD @the_TE_guy]

Another group following up on the work from my PhD, linking LINE-1 transposon expression to aging phenotypes!

[medRxiv @medrxivpreprint]

Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespan https://t.co/GhQyOskogY #medRxiv

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Parental age selection in C. elegans influences progeny stress resistance capacity

https://t.co/o7tfGriLme

[Proteomics Daily News @Proteomicslabo]

🔬 Developed a multi-omics approach to analyze Alu transposon impacts on fibroblast aging pathways.
🔗 https://t.co/hWtBnD96Iy
#Proteomics #MassSpec

[Aging Science News @AgingBiology]

The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors
https://t.co/dGfiAvBVi5

[Aging Science News @AgingBiology]

Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals
https://t.co/dC2B0gdqTQ

[Carlos Mendez-Dorantes @CarlosMendezPhD]

New pre-print: We show that L1 insertion intermediates can recombine with one another or with DNA breaks to form genome rearrangements, highlighting the risk of L1 retrotransposition generating substrates for aberrant recombination and genome instability.

https://t.co/Uumlubebyb

[Cell Genomics @CellGenomics]

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development https://t.co/jBy0rG3FFp

[Aging Science News @AgingBiology]

A noncanonical cGAS–STING pathway drives cellular and organismal aging
https://t.co/gw0kMRsif3

[CBU @CBUuniTo]

Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases
https://t.co/IraqNNEJOq

[Aging Science News @AgingBiology]

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways
https://t.co/ypdFc448bg

[bioRxiv Genomics @biorxiv_genomic]

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways https://t.co/2PMGK0Z3ET #biorxiv_genomic