Josh Do

[RJC @RJCcapital]

Fibonnacci deez nuts scrub

[Zephyr @zephyr_z9]

Jensen was super pissed

[Donald Dean @donaldjdean]

$IREN IREN - Is the bottom in?

Price Targets: $44.44, $51.45, $74.15

IREN has shown consolidation and looks to have potentially bottomed. Price needs to break above the trendline around $42 to make the next legs higher.

Targets are set at the 50% retracement level at $44.44, the 618 Fib level at $51.45 and $75.15 to challenge previous resistnace.

[Bryan Johnson @bryan_johnson]

Here's how I achieved a 9 year skin age reversal. Effectively freezing my skin aging over the past 5 years.

To start, some first hand accounts:

1) Chamath: "Bryan's skin is incredible. His skin is like a porcelain dolls. Both my wife and I were like, we've never seen skin like this. It's incredibly soft. It's the softest skin I've ever touched in my life."

2) Growing Daniel "Eight feet from immortal unc right now. His skin is so beautiful in person. Cameras can’t comprehend."

Skin is an accounting of life decisions. It's a tell all. Eat a bag of doritos and you'll wear it on your face.

Skin begins to age in your 20s.

+ collagen and elastin decline: starting in our mid 20s, collagen content decreases by about 1% annually, reducing skin firmness and suppleness. Elastin, which provides stretchability and prevents wrinkling, also deteriorates over time.

+ loss of hydration: aging skin loses moisture due to changes in collagen, reduced hyaluronic acid content, and a 65% loss of fat content, leading to dryness, reduced thickness, and diminished suppleness.

+ environmental damage - chronic exposure to environmental factors, especially UV radiation and air pollutants, accelerates skin aging by breaking down collagen and inducing oxidative stress. This damage is largely avoidable through deliberate lifestyle planning.

+ cellular aging: fibroblasts, responsible for collagen and hyaluronic acid production, become less efficient, impairing skin repair and water retention. A drop in active melanocytes also causes the uneven pigmentation typical of elderly skin.

My protocol is comprehensive: nutrition, supplementation, environment, and therapies. Designed to protect the skin from cellular radiation damage, prevent environmental toxic exposures, prevent inflammation and oxidative damage, improve skin hydration, boost blood supply and circulation, enhance detoxification, and optimize the skin microbiome.

Daily Skin Routine
Get the basics right: cleanse, hydrate and keep inflammation and cellular damage at bay.

During the past five years of my project blueprint, I've experimented with dozens of serums. The companies making these products overpromise. Few are based upon evidence. Fewer do anything. We reviewed the scientific evidence and found the actives we wanted. But it didn't exist. So we built it.

A blueprint cleanser, serum and moisturizer, featuring SCF, NMN, and hyaluronic acid as core active ingredients.

SCF is a novel skin anti-inflammatory and anti-aging compound, showing superior effects to niacinamide (the state-of-the-art in most creams). In cultured cells, it demonstrated superior properties to antioxidant vitamins in preventing inflammation linked to UV exposure and chemical or bacterial insults.

In a clinical trial, 1% SCF statistically outperformed 5% niacinamide at reducing skin wrinkles, improving texture, hydration, radiance, luminosity, and brightness, as well as improving the overall healthy appearance of the skin.

NMN (Nicotinamide Mononucleotide) is an NAD+ precursor. Systemic administration of NMN is known to prevent skin aging by improving skin barrier function and enhancing antioxidant and anti-inflammatory defenses against UV damage. Experiments with synthetic skin models also showed that NMN can penetrate the skin, indicating that topical applications can enhance the benefits.

Hyaluronic acid retains moisture, granting the skin extra firmness and an improved texture.

Diet and Supplementation

Oral collagen peptides, flavonols, polyphenols, and antioxidant supplementation help the skin resist photoaging and maintain its elasticity.

+ average collagen users: showed better skin elasticity than 97% of the control group.

+ average flavonoid users: showed better skin resistance to UV than 99% of the control group.

+ average polyphenol users (a mix of flavonols and other polyphenols): Showed better skin elasticity than 97% of the control group.

+ I supplement NR (Nicotinamide Riboside) and hyaluronic acid daily.

I get all of the above from Blueprint: collagen peptides, extra virgin olive oil, cocoa and supplementation as I know its sourcing, quality and it's third party tested.

My diet, which focuses on plant protein, fiber, and polyphenols, is also geared toward eliminating inflammation, oxidative stress, and glycation. All sources of skin damage.

Photoaging and UV Precautions
+ early mornings and later afternoons are better when the UV index is low
+ when the UV index is high (10 am - 4 pm), protect your skin
+ can protect with clothing, a UV umbrella, hat and/or mineral sunscreen

Skin focused therapies

+ 1927 nm laser (1x every 6 months, can do more or less depending on your status and goals) - improves skin tone, texture, dyschromia, sun damage, and fine lines, while also reducing actinic keratoses and pigmentation through accelerated epidermal turnover and renewal.

+ 1550-nm laser (1x every 6 months, can do more or less depending on your status and goals) - penetrates deeper into the mid-dermis, where it creates controlled microthermal injury that stimulates fibroblasts to produce new collagen and elastin, leading to improvements in skin firmness, wrinkles, acne scars, and overall structural integrity.

+ Sofwave (1x every 6 months, can do more or less depending on your status and goals): non-invasive ultrasound skin tightening system that delivers controlled energy into the mid-dermis to stimulate collagen and elastin production without damaging the skin’s surface. By activating fibroblasts through precise thermal stimulation, it improves skin firmness, laxity, and fine lines, especially on the face and neck, with minimal downtime.

Systemic therapies

+ red/nir light panels: I do a daily therapy using full body panels with 660nm and 850nm wavelengths. By boosting mitochondrial function, vasodilation, and blood circulation, this therapy offers both localized benefits for skin health (including boosting skin energy and vitality, improving antioxidant defenses, and reversing damage) and aids in muscle recovery from exercise, as well as boosting systemic health, including improving sleep, immunity, and metabolic regulation.

+ Hyperbaric Oxygen Therapy (HBOT): is perhaps the best skin rejuvenation therapy in the world. Data from 60 sessions, 90 minutes each. 20 min oxygen, 5 min off. 5x weekly, 12 weeks.

+ 12.8% increase in collagen fiber density
+ 144% increase in elastic fiber length
+ reduced fragmentation 90% to 10%
+ 40.9% increase in skin blood vessel count
+ 84.3% increase in CD31 blood vessel specific marker
+ 21% reduction in senescent cells

+ dry sauna: sauna improves skin health by shifting blood flow towards the skin (up to 70%), promoting improved oxygen and nutrient supply, increasing sweating for pore cleansing and detoxification, and improving collagen and elastin production as a heat response.

[ₕₐₘₚₜₒₙ @hamptonism]

These are the quants you’re competing against in China.

Good luck.

[_aestheticprimal_ @aestheticprimal]

Sounds extremely simple, because it is, but:

The oral microbiome DIRECTLY influences the gut microbiome

this is why having a proper oral hygiene routine is so crucial:
- Miswak brushing
- Black seed oil swishing
- Propolis/Mastic chewing
- flossing

[Brian Grimm, M.D. @DrGrimmMD]

Dentists blamed Strep mutans for cavities.
Cardiologists found it living inside arterial plaque biofilms.
Now a 2025 Nature Comm paper shows it hijacks dopamine neurons in Parkinson’s by pumping out a metabolite (Imidazole Propionate) that flips mTOR and shuts down cleanup.

One bug. Three systems. Same trick: mimic the host’s current, build a biofilm fortress, jam the signal.

Lay lens: stomach acid is supposed to burn this bug off. GERD meds lower that acid “firewall,” letting it survive the trip to the gut. Once there, its chemical chatter makes it all the way to the brain.

Field lens: dopamine neurons are already running hot, calcium load, iron redox, neuromelanin. ImP just tips them over. And the same mimicry that lets S. mutans nest in arteries is now desynchronizing light-coded dopamine circuits.

The real question isn’t just “do you brush enough?”
It’s: how much of Parkinson’s and heart disease is really dental?

[CL @CL207]

stocks is truly goated

you buy, and now the most powerful, corrupt, smart, insider, elite, educated people work their ass off everyday just to pay you dividends

[Rep. Jack Kimble @RepJackKimble]

I wanted to make a quick apology. Last night, I referred to President Bukele of El Salvador as President Bukkake. This was the fault of spell check and not me. When you type a word a lot spellcheck will start to change words that are close to it. I will be complaining to Apple

[ctrl @maybectrlfreak]

I was born in the right generation I love artificial intelligence, cigarettes, Hyperliquidity Provider, Chrome Hearts, JBL speaker, backshots, strong zero and For You page

[gainzy @gainzy222]

Thailand has the best lifestyle assuming you’re active

Average day wake up, go to beach club, breakfast 1$, massage on beach 15$, ride jetski 30 min 30$

Train muay thai 40$, gym 5$, hit sauna/cold plunge 10$, late lunch fresh food 10$

Walk around town/shop 10$, dinner/bars 20$

[FREE TO A GOOD HOME ♅ @Izzytr0n]

gay for the money call me a baggot

[ram jr. @ramonos]

2025 so far:

- Melania Rug
- Cuba Rug
- Brasil Rug
- Peru Rug
- African Country Rug
- UFD “hack”
- JellyJelly rug
- Portnoy being Portnoy
- Milei rug
- Sol dumps from $280 to $140
- Bybit Hack
- Suicide on Stream
- OXFun insolvency
- Kanye plans to launch

Sigh, what else?

[Elon Musk @elonmusk]

美しい魂

[Coffeezilla @coffeebreak_YT]

"ye might launch a token"

[Wei Wu 吴伟 @WuWei113]

Much people fail because they IQ too high.

My friend most smart. IQ = 175. She genius. She have world most greatest idea. But she choose not take action. I ask why? She give me 1,000 reason why idea maybe not work.

This give me wisdom. If her IQ only 95 and she have smart business idea, she take action because she do not see 1,000 reason why she fail in future. If she take action, maybe she be success! But her IQ so high, she not take any action.

My friend. Sometime, best take action. Do not worry how your idea be fail. Just take action. Even if you most high IQ, try make self low IQ for short time. Be dumb ass, then you be rich.

Absorb this dumb ass wisdom.

[Dave Portnoy @stoolpresidente]

*update.

Just launched Greed 2. Don’t invest in this collectible coin with more than you can afford to lose. It’ll be volatile. I will not sell 1 penny till at least midnight est or maybe never. Be careful.

GoL6RVGQFzTD7MdoNEHUQmNp6SgXBn6f9khxAW5Bpump

[Duolingo @duolingo]

an important message from Duolingo

[Eric Trump @EricTrump]

In my opinion, it’s a great time to add $ETH.