We trained a foundation model of patient biology that predicts drug response from a single biopsy before treatment.
As a case study, we tested on a phase 3 trial of ustekinumab in IBD and get a 0.76 AUROC, enough to run it with ~450 fewer patients at the same statistical power.
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Everyone obsesses over Starship's height and thrust.
The number that actually matters: cost per kg to orbit.
Falcon 9 brought it from ~$54,500 (Shuttle era) to ~$1,500. Starship targets <$100.
A 500x reduction in 25 years. That's the curve enabling Mars, lunar bases and orbital industry. Everything else is a consequence of that one number.
Starship Version 3 with humans & @cybertruck for scale.
Ship 39 and Booster 19 standing tall at Pad 2 following a seemingly successful wet dress rehearsal earlier this morning.
📸 - @NASASpaceflight
T-Mobile is making it easier to sign up for SpaceX’s @Starlink Mobile service by allowing customers to enroll online, eliminating the need for an in-store visit or a phone call.
T-Satellite costs $10/month for satellite connectivity in the carrier’s dead zones and supports texting and data for select mobile apps.
AI will help build the energy it needs.
At the #SCSPAIExpo, NVIDIA's Ian Buck spoke to two decades of NVIDIA supercomputing with the national labs, and a Genesis Mission ready to deliver.
"NVIDIA is 100% committed and invested in Genesis." — Ian Buck
Read the full recap: https://t.co/2Rk5zQSUkh
$UBER +9% pre-mkt after guiding to stronger than expected 2Q gross bookings and beating on 1Q gross bookings while narrowly missing on 1Q revs. The strong 2Q outlook signaled that robust demand from US travelers is likely to offset the impact from geopolitical tensions in the Middle East.��
Uber’s core US rideshare business will “accelerate further” this year, CEO Dara Khosrowshahi said in prepared remarks. Heightened insurance costs, which had contributed to higher fares and weighed on the US business, have been moderating, leading to meaningfully improved trip growth in the hardest-hit markets, such as SFO and LA.
Conference call 8am ET likely to focus on efforts to build out autonomous ride hailing capabilities with a growing stable of partners.
2Q FORECAST
- Gross bookings $56.25B - $57.75B vs $56.23 B est.
- Adj EPS 78c to 82c vs 80c est.
- Adj Ebitda $2.7B - $2.8B vs $2.64B est
1Q RESULTS
- Gross bookings $53.72B, +25% y/y, vs $52.92B est
- Mobility bookings $26.39B, +25% y/y, vs $25.82B est
- Delivery bookings $25.99B, +28% y/y, vs $25.76B est
- Revenue $13.20B, +14% y/y, vs $13.3B est
- Adj Ebitda $2.48B vs $2.44B estimate
- Ad EPS 72c vs 70c est
- Trips 3.64B 20% y/y, vs 3.64B est
- Monthly active platform consumers 199M +17% y/y, vs 198.45M est
Commentary
- CEO: “We expect the U.S. Mobility business to accelerate further in 2026”
- “We continue to execute on our barbell strategy across the price spectrum. At the low end, we’re focused on affordability and access. In the core, we’re keeping prices stable through strong supply and product improvements”
- “Reaching 50 million Uber One members is an exciting milestone as we execute against our platform strategy, with members now driving half of our Gross Bookings across Mobility and Delivery”
Prepared remarks: https://t.co/XXFjwRWH4P
NYT: "Trump's empty promises - shipowners don't trust the US and demand the inclusion of Iran in any plan for the Strait."
Companies are hesitant to send their ships through the Strait of Hormuz, and some of them claim that the US proposals to persuade them are not enough.
These companies emphasize that for a large number of ships to pass through the strait, Iran must be part of any plan or agreement.
I was insanely nervous the first time I applied to YC.
I agonized about it for weeks.
When I look at it now, that application was so embarrassingly bad. But it was a start.
And it directly led to getting in to YC W22. And that changed my life. The deadline is today. All you need is an idea.
If you need last minute feedback, my DMs are open. We try to pay it forward and help as many people as we can.
BREAKING: Starship Flight 12 NET May 12, 22:30 UTC / 17:30 CDT
An advisory has appeared on the CADENA Operational Information System.
- NEW Trajectory
- Afternoon Launch Window
The window spans 22:30 - 00:43 UTC, which is 17:30 - 19:43 Starbase local time.
Instead of flying the corridor between Florida and Cuba, Starship Flight 12 appears to be targeting a more inclined corridor, threading the needle between Mexico's Yucatán Peninsula, Cuba, the Cayman Islands, Jamaica, Haiti, and the Dominican Republic.
Despite this change in launch trajectory, splashdown remains in the Indian Ocean, with a corridor running through Madagascan, Mauritian, and Australian airspace.
🗺️ CADENA Operational Information System
Credit to @NeedPizza42 for spotting
I drove over 3,000 miles this past week & I still didn’t come in first on @wholemars’s FSD database 😂
The Wis is an absolute legend
@TheWis65@fsd_database
Hyundai has unveiled their next-generation infotainment system called Pleos, which looks to be inspired by Tesla.
The company plans to equip 20 million Hyundai, Kia and Genesis vehicles with this new system by 2030.
At the core of Pleos is Gleo AI, a voice assistant built on a large language model (LLM):
• Context-Aware: Gleo AI uses conversational and driving context to accurately interpret abstract commands like “navigate there” or “find a restaurant near here.”
• Multi-Command Processing: It can recognize and execute multiple commands within a single request.
• Web Searches: It can also respond to user questions on topics such as the news, weather and sports through web searches
• Integrated Vehicle Control: Users can manage navigation, adjust climate settings and access vehicle manual information using natural language.
• Zone-Specific Recognition: The system can identify the speaker’s location within the cabin to execute precise commands, such as “turn on my heated seat.”
Large Central Screen: A wide-view display divided into three main sections:
• The Driving Information Screen shows essential data including speed and warning lights, along with 3D graphics of surrounding objects and people.
• The App Screen is used for navigation, media and third-party applications. It can be switched between the Single Screen mode for immersive content, and the Split Screen for multitasking.
• The Bottom Bar provides one-tap access to recently used or pinned apps.
Yep, Tesla has officially added “Navigation” as a selectable disengagement reason in the just updated FSD popup in V14.3.2 (software version 2026.2.9.9).
Picture from my Model Y screen: