$AXSM new 52 week & all-time high. Management continues to execute on all metrics. Quite a unique company โ- certainly not lost on BigBioPharmas ๐ฅ๐ฅ๐ฅ
$PFE | RBC Capital ๐ฎ๐ฉ๐ ๐ซ๐๐๐๐ฌ ๐๐๐ข๐ณ๐๐ซ to Sector Perform, maintains ๐๐ ๐๐ญ $๐๐
Analyst sees risk/reward as more balanced after the stock's recent -11% decline, prompting a move to the sidelines ahead of key 2026 catalysts.
$TGTX new 52 week high today. The enthusiasm from the recent updates and presentations at Jeffries & Goldman Sachs Healthcare Conferences continues to raise the companyโs profile๐ฅ
$TGTX GS expects to reach a ~$1B run-rate before end of this year,
supporting >$1B annual revenue thereafter, broadly aligned with consensus (>$1B
est in 2027). Importantly, believes that its IV business alone can
generate peak revenue multiples above where it is today, with a multi-year runway to
peak given continued share gains over at least the next 3โ5 years (vs. ~20% dynamic
share today, within the ~40K patients available for new CD20 therapy per year)&peak not expected to occur until ~5 years after share stabilizes, reflecting a long tail
of patient accumulation.
So not only have the $CRWV execs sold almost a quarter of their holdings since going public, but Magnetar has cut its holdings in half, as wellโฆ?! Lol, ok.
$TGTX Double top breakout today. News flow continues to be very positive and excellent presentations at multiple healthcare conferences. Management comments continue to lead to accelerating revenues and earnings. HUGE short interest could be a POWDER KEG on short covering ๐ฅ๐ฅ๐ฅ๐ฅ
$TGTX 82% of subjects achieved an MCID in their MG-ADL with a mean >4 point improvement in MG-ADL observed in Phase 1 study of Subcutaneous BRIUMVI in patients with MG (n=11)
Potential registration-directed Phase 2 trial utilizes novel sequential treatment approach designed to combine rapid symptom control of FcRn inhibition with sustained disease modification of B-cell depletion therapy
At baseline, patients had clinically meaningful disease burden, with mean baseline Myasthenia Gravis Activities of Daily Living (MG-ADL) of 8.24 (range 6 โ 13) and mean baseline Quantitative Myasthenia Gravis (QMG) score of 12.0 (range 7 โ 22).
Key Data Highlights:
โขConsistent reductions from baseline were observed across all myasthenia gravis outcome measures over time following treatment with subcutaneous BRIUMVI
โขAt Week 24, 82% of patients achieved the Minimal Clinically Important Difference (MCID) in MG-ADL, defined as a decrease of โฅ 2, with a median time to MCID of 30 daysย ย
โขOverall, a mean 4.6 point improvement in MG-ADL was observed at Week 24
$ZEAL $RHHBY another one bites the dust! Small cap beauty $VKTX still remains the โpick of the litterโ as far as outstanding safety & efficacy in the $150 Billion Obesity market. It still looks like there are a great many BigBioPharmas with no impact in this spaceโ-what could they be thinking??๐ฅ๐ฅ๐ฅ
$zeal Survodutide has the poorest performance of all GLP1 class. Efficacy estimand 13%
Vomit rate 45%
DC rate due to AE is 25% ( vs 6-8% with $NVO semaglutide ). Total DC rate 35%
This muscle sparing is the most nonsense I heard including from endocrinologists on this platform. Terrible molecule. Looks as expected glucagon here only adds toxicity.
Liver fat reduction will be discussed later but also poor performance and barely competitive with $MDGL drug with major tolerability issues. Not even close to $LLy tirzepatide performance ( from NEJM phase 2 )
This molecule is dead on arrival.