K Titus

[K Titus @titusk99]

I'm excited to share our new publication in @CellGenomics! We examine the structure-function relationship between chromatin looping and RNA polymerase II-mediated gene expression during neural lineage commitment.

Check it out!
https://t.co/2Ea8CEu913

[K Titus @titusk99]

Finally, I'd like to give thanks to @simandi_zoltan, @HarshiniChandr8, and @PaquetLab for their critical wet and dry lab contributions and @CreminsLab for guiding me through the scientific discovery and writing process. Without them, none of this would've been possible! (5/5)

[K Titus @titusk99]

I'm excited to share our new publication in @CellGenomics! We examine the structure-function relationship between chromatin looping and RNA polymerase II-mediated gene expression during neural lineage commitment.

Check it out!
https://t.co/2Ea8CEu913

[K Titus @titusk99]

We also demonstrate that loops anchored by elongated genes are particularly sensitive to short-term RNA Pol II perturbation, whereas loops anchored by initiated genes bound by CTCF are protected. (4/5)

[K Titus @titusk99]

We uncover a strong link among cell-type-specific enhancer-promoter loops gained de novo during differentiation, the transition to RNA Pol II elongation from initiation, and a robust increase of gene expression. (3/5)

[K Titus @titusk99]

We create genome-wide reference maps of long-range chromatin loops, RNA Polymerase II (RNA Pol II) occupancy, and gene expression during the transitions from human induced pluripotent stem cells (hiPSCs) to neural progenitor cells (NPCs) and NPCs to post-mitotic neurons (2/5).