As a medical school professor, I teach about APOE4 -- the gene that makes you 2.5x more likely to develop Alzheimer's. We've told patients there's nothing they can do about it.
A new JAMA Network Open study of 2,157 adults just proved us wrong.
Higher meat consumption completely abolished the APOE4 dementia risk.
The data:
-> APOE4 carriers with highest meat intake: 55% lower dementia risk
-> Their typical 2.5x excess Alzheimer's risk? Gone entirely
-> Cognitive decline reversed: +0.32 standard deviations over 10 years
-> Unprocessed meat was protective; processed meat was harmful regardless of genotype
Researchers propose APOE4 is an evolutionary adaptation to meat-rich diets. The gene isn't a defect -- we just stopped feeding it correctly.
This is personalized metabolic medicine. Your genes load the gun, but your diet pulls the trigger -- or puts the safety back on.
Full breakdown coming on the Health Longevity Secrets podcast.
Source: https://t.co/4CxyiDzi0d
#APOE4 #Alzheimers #MetabolicHealth #Nutrition #HealthLongevity
@SamaHoole Correct! I love oysters, mussels and magret de canard (save the fat for cooking) too. Did you know they have a fete de gras in French supermarkets when you can buy lots of fatty meat? Keep posting, really appreciate your takes. Thank you :)
Higher protein intake and higher muscle mass are associated with lower mortality rates
Study was of ~6400 people.
Magnitude of effects were striking: for protein, 2x the protein consumption was associated with 50% lower mortality risk, with no apparent upper limit.
For muscle mass (estimated by creatinine excretion rate index), each standard deviation increase was associated with 21% lower mortality.
Getting sufficient protein, which many or most people do not get, appears a powerful way to decrease mortality risk and hence extend lifespan and healthspan.
Note: that's contrary to what many life extension influencers will tell you.
Animal protein such as meat, eggs, fish, and dairy has the highest quality protein.
Building muscle through resistance training also powerfully reduces mortality.
https://t.co/kcxlnxf4ZX
*Thread*
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