Tom Jackson

Postdoctoral Fellow in the Puigserver lab at the Dana-Farber Cancer Institute and Harvard Medical School

[Puigserver Lab @puigserver_lab]

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency.

https://t.co/m71gz29mUv

[Nature Cell Biology @NatureCellBio]

💫NEW by @puigserver_lab & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://t.co/WzXCi3soyQ
https://t.co/bdiL8phsg9

[Tevis Vitale @TevisVitale]

Thanks to @FrezzaLab for the great News & Views on our new paper in @NatureCancer!
https://t.co/pkU8Htye67

[Tom Jackson @TomJackson1995]

Great to see this exciting work published showing how tumor mitochondria can be targeted to enhance anti-tumor immunity. Happy to have been able to contribute!

[Tevis Vitale @TevisVitale]

After much anticipation, I'm glad to say that the first paper from my Ph.D. is now out in @NatureCancer! Thanks to all the co-authors for their input and hard work!
https://t.co/Z1qQhGxQXI
Below is a 🧵detailing our results 1/7

[Puigserver Lab @puigserver_lab]

New article by @platorremuro published in @NatureCellBio Molecular mechanisms of ER stress-inducible chaperones mediating outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity and diabetes https://t.co/NIzg6wJcdI

[Puigserver Lab @puigserver_lab]

New paper by @platorremuro published in @CellCellPress! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.

[Tom Jackson @TomJackson1995]

@MeganJBaker24 @JCellBiol @DrDStojanovski @UniMelbMDHS Congrats Megan!

[Megan Baker @MeganJBaker24]

Amazing to see our work on the mitochondrial CLPB disaggregase finally published in @JCellBiol! Thank you @DrDStojanovski and @UniMelbMDHS for all your support!

CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex https://t.co/RYpWEp7wL3

[Puigserver Lab @puigserver_lab]

Excited to share our latest preprint by postdoc @platorremuro in collaboration with @vivekvivsharma and #LiaoLab. We combined #physiology and #cryoem to determine respiratory supercomplex adaptation in brown adipocytes in response to cold environments: https://t.co/CqPDV9jx6u

[Puigserver Lab @puigserver_lab]

New studies from @puigserver_lab at @DFCI_CancerBio @HarvardCellBio finding Mitoribosome Quality Control as protective mechanism against pathogenic human mitochondrial disease mutations, published @emboreports https://t.co/kOOnA5sKOa

[Puigserver Lab @puigserver_lab]

New area of study from our research program on mitochondrial biology; “Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity”, including sensitization to immune checkpoint blockade; pre-print at @biorxivpreprint; https://t.co/1Ro2oOBg6O

[Puigserver Lab @puigserver_lab]

Our latest paper published now in @NatureComms: Epigenetic suppression of PGC1α can sensitize BRAFi-resistant melanomas to HMGCR inhibitors, check it out! https://t.co/pUPC1vQqnh @DFCI_CancerBio @HarvardCellBio @GygiLab @bwhdermatology

[Clemons Lab @Clemons_Lab]

WE'RE HIRING! ☀️ Clemons Lab @PeterMacRes is expanding and looking for a talented postdoc or research assistant to help investigate immunotherapies in gastro-oesophageal cancers. If you have 🐁 experience and interest in cancer biology, join our team! Details/apply 👇 Please RT!

[Tom Jackson @TomJackson1995]

Great work from the big man @KenjiFujihara and @Clemons_Lab. Excellent study showing that eprenetapopt can induce ferroptosis.

Great to watch the project develop over the years, and happy to have had the opportunity to be involved.

[Tom Jackson @TomJackson1995]

@ae_frazier @DrDStojanovski Thanks Ann :) Glad to have you involved

[Luke Formosa @drlukey_form]

So excited to see @JessicaSpinel16 present next week! It is sure to be some beautiful and elegant #biochemistry for #mito enthusiasts!

[David Stroud @thestroudlab]

Many of us have done sodium carbonate extractions to determine the membrane association of a single protein, but have you done it on >840 mitochondrial proteins at the same time, across two pH and multiple KO cell lines? Check out our new paper on SCE-MS: https://t.co/nUqED2DA8e

[Tom Jackson @TomJackson1995]

@thestroudlab Nice one Dave Robinson and all other authors - doing a great service to the community. Will another carbonate extraction ever need to be performed? Ultracentrifuges can be decommissioned now

[Tom Jackson @TomJackson1995]

@drlukey_form @nhmrc @MikeRmitolab @MonashBDI @Monash_FMNHS Massive! Congrats Luke

[Luke Formosa @drlukey_form]

Looking forward to hearing all about some amazing mitochondrial biology!!