@iamyouornot Es una muy buena pregunta. Repararía todo mi sistema digestivo o me aseguraría de que todo funcione bien. Con eso como prioridad, no me preocuparía por la asimilación de los nutrientes, porque sabría que todo de lo que me alimento lo hace de verdad.
@paleoancestral@LiamCristiano Sí, continúo muy alto en carbohidratos. No me pasa que sufro por antojos absurdos ni tampoco peleo con evitar "cortisol" con los alimentos. Y si, al menos recomendaría respetar el ciclo de Randle.
@iamyouornot Un carnívoro o un peater pueden tener las mismas deficiencias. Y es aún más probable que el segundo tenga más dificultades de asimilación que el primero.
Subir de peso, músculo, es diferente a retener líquidos. La retención principalmente la verás en los pies, digamos zonas periféricas, y ese tipo de retención si es renal. Creo que diferenciar eso te dará un buen panorama. Personalmente: 1) No hago Peat como tantos divulgadores por aquí, no me verás comer pasta, panes, galletas, pizza porque no es sano. No creo que la masa madre sea sana. 2) Mi objetivo si fue subir de peso, y en eso sí me apoye de los carbohidratos. 3) Yo respeto el ciclo de Randle. 4) Tengo otros casos en los que hemos logrado documentar el descenso de peso con carbohidratos.
You need to be eating more organic acids
Acetic acid (vinegar): improves satiation, promotes insulin sensitivity, AMPK activation
Citric acid: improves mineral absorption, prevents kidney stones, antioxidant effects
Glucuronic acid: improves estrogen detox, liver detoxification, antioxidant effects
Lactic acid: regulates gut microbiome, improves mineral absorption, activates immune function
Apple cider vinegar, citrus fruit, lemon juice, pickles, kombucha, kefir, and yogurt are all great ways to get these in your diet
Dibasic acids like citric acid react with divalent cations like magnesium, calcium, zinc, and iron and help solubilize them improving their absorption
@Rustkolnikoff Si, probablemente porque sientes que te inflama. Pero lo he visto, colonizaciones algo agravadas, mucosa tocada y problemas de hígado. Espero que no y que todos podamos sacar buenas conclusiones de tu valiente experimento.
Beyond magnesium depletion during stress, vitamin B1/thiamine is one of the most important nutrients to consider that also runs low.
It's very difficult to get in your diet in adequate amounts unless you ensure you cover regular nutritional yeast, pork, and salmon intake.
So supplementation *can* be leveraged (more on that below)
Vitamin B1 is required for 4 of the most important enzymes in your energy metabolism and when any of them bottleneck the downstream chaos is horrific.
The 4 enzymes being: pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, branch chain keto acid dehydrogenase, and transketolase all require B1.
When pyruvate can't get into the mitochondria you back up into lactate, you potentially spill into oxalates via glycine and pyruvate forming alanine and glyoxalate, and you starve your cells of acetyl-CoA which disrupts glucose metabolism, mitochondrial ATP/H2O production, myelinogenesis, acetylcholine production, inhibits vagal tone, drives sympathetic overactivation, slows gut motility, and sets the stage for SIBO/dysbiosis, dysautonomia/POTS, metabolic disorders, and neurological/neuropsychiatric issues.
When alpha-ketoglutarate dehydrogenase bottlenecks you can get glutamate accumulation which drives excitotoxicity. Whilst magnesium dependency further goes up, and the TCA cycle is stalled.
And that's before you even get to transketolase in the pentose phosphate pathway (PPP) which needs B1 to keep NADPH regeneration running for glutathione recycling, detoxification, fatty acid synthesis, steroid/thyroid hormones, and immune response. This is also on top of PPP being necessary for making DNA, RNA, FAD, NAD, CoA, and ATP.
Testing for B1 status is very challenging too, because RBC transketolase activity is the gold standard but barely available outside of research.
So you have to learn to spot it through patterns on an OAT test (lactate/pyruvate ratio, alpha-ketoglutarate, branch chain keto acids, oxalates), plasma alanine, serum bicarbonate, and a handful of other clues like creeping fasting glucose, weird tingling/neuropathy, fatigue under higher carbohydrate intake, or even tachycardia.
Supplementation shouldn't start until you cover your micronutrient needs via Cronometer, because B1 turns on energy metabolism and shuttles more electrons into the ETC. This means vitamin C + E, glutathione (cysteine/methylation nutrients + glycine/collagen), selenium, copper, zinc, B2, B3, and polyphenol-rich foods are of importance.
Then you could look into B1 HCL at ~50mg, ramping up from there. The other forms (benfotiamine / TTFD) are more specific and potent, and can be leveraged if success from the HCL form. But slow and steady wins the race.