every guy i’m friends with knows to not say that word around me. as men, i don’t think that word ever needs to leave their mouths. i always say im not the word police, but if you consider yourself a friend of mine, you would be mindful and most of them are
Mayor Mamdani is starting a new direct-to-camera series called "Morning Pitch," where he'll share weather, transit & tournament updates before every NY/NJ World Cup match day.
He kicks off the first talking about the Knicks: "I have just 3 words for my fellow NYers: Knicks in 5.
We now have a female Bryan Johnson.
It’s Kate Tolo.
She will become the most measured female in history.
+$2 million of spend per year
+ Developing a female-specific protocol
+ Sharing everything for free
To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks.
+ 3 months for baseline measurement
+ across 4 time points per cycle
+ doing the same thing every day
+ a dedicated full-time medical team
For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started.
The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions.
We will try to answer practically useful questions and share all of the data + learnings for free.
Can fertility be improved?
+ Should women cold plunge?
+ Can PMS symptoms be alleviated?
+ What should a female sauna protocol be?
+ Should dosage change throughout the month?
+ What keeps a cycle regular?
+ Does the body need more iron, magnesium, or protein at specific phases?
+ Should women fast?
+ Should recovery protocol change by phase?
+ What's the earliest detectable signal of perimenopause?
+ Can perimenopause be slowed?
+ How is cognitive load & mood affected?
+ Does stress impact men and women the same?
Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover.
Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies.
She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is.
In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol.
Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do.
N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women.
If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence.
It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans.
At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly.
The beginning of the world’s first n=2.
we see new stories like this every other day, and there are 30-40 year old women saying “good men are out there and i won’t stop until i find my husband.” the quiet part of this is “im different from (smarter and better than the lesser) women who keep getting femicided.”
God does not bless any conflict. Anyone who is a disciple of Christ, the Prince of Peace, is never on the side of those who once wielded the sword and today drop bombs. Military action will not create space for freedom or times of #Peace, which comes only from the patient promotion of coexistence and dialogue among peoples.
when i was 260 pounds, people treated me like a dog. when i was 200 pounds, people treated me like a dog who did a cool trick & deserved treats contingent on more cool tricks. when i was 120 pounds, people treated me like a person! then i hit 90 pounds & everyone was like Omg Why
I think what I hate the most about being gen z is how I not only saw the transition of this
But only got to experience the world before minimalism for a brief few years before I could really maintain stronger memories
big time rush was before one direction. and big time rush literally invited one direction to open for them on tour which then led to one direction’s popularity in america. we are losing the ancient texts 💔
I think the contradiction between wanting sex and pleasure and constantly being let down by men and attracted to the dumbest ones is pretty spot on for being 26. It also requires a good deal of vulnerability and admission of your own flaws to write songs like that.
RIP to all the gold girls who are getting silver jewelry tomorrow and to all the silver girls who are getting gold jewelry tomorrow and to aaaaall the girls who are getting ugly ass heart shaped jewelry tomorrow!
hope you break up with your boyfriends 🩷🩷🩷