THE REAL 💯D👀KS💯

💯D👀KS💯 | co-founder of 💯club💯 | chemical researcher and managing partner of Elite Research USA | life’s too short to be soft little bitch | #DOWORKSON

[THE REAL 💯D👀KS💯 @trinity2pointO]

@ernestosrib @BowTiedYukon Now that’s a badass dog

[THE REAL 💯D👀KS💯 @trinity2pointO]

@doctorcalf Dude! Those take a lot to make… people bitch at me for the price and I just don’t think the understand the CD addition and the delivery mechanism. Thanks for letting me know.

[THE REAL 💯D👀KS💯 @trinity2pointO]

@clsesq @BowTiedYukon Yeah good looking dog right there

[THE REAL 💯D👀KS💯 @trinity2pointO]

@KeeptheWaB @BowTiedYukon Shepherd was my first dog. Probably my favorite breed.

[THE REAL 💯D👀KS💯 @trinity2pointO]

@coreyh712 @BowTiedYukon Oh dude yes 🙌

[THE REAL 💯D👀KS💯 @trinity2pointO]

@SethShenk77 @BowTiedYukon Lmfaooo 😂

[THE REAL 💯D👀KS💯 @trinity2pointO]

@MeesesRfriends It is

And it is not pre-complexed

[THE REAL 💯D👀KS💯 @trinity2pointO]

Prob Friday.

[Familybucs fans @Familybucsfan]

@trinity2pointO ETA?

[BowTiedYukon @BowTiedYukon]

UNLEASHD Friday!!!

Let’s see pic of your dogs or cats in the comments!!!

Maple, Moose & Murphy

[THE REAL 💯D👀KS💯 @trinity2pointO]

Literally one of the most underrated compounds.

[Elite Research USA @EliteresearchUS]

KPV is typically sold in 250mcg-500mcg capsules and is on the expensive end

In the disease/longevity world KPV is known for a wide range of potent effects and if often used by functional and naturopathic doctors in disease therapy.

From autoimmune to cancer.

I’ve personally seen this change so many lives, it actually changed my life when I was in my own battle.

So I decided that we would not only release the highest doses KPV on the market but we would actually sell it for the price other companies sell 250mcg for, so that everyone that actually needs it can afford it

*research use only not for humans*

[THE REAL 💯D👀KS💯 @trinity2pointO]

@AWar1586398 Ha! Dude what a cool fkn product right?!

[THE REAL 💯D👀KS💯 @trinity2pointO]

Lead, follow, or gtfo 😃🐾🐶🐕

Soon…

[THE REAL 💯D👀KS💯 @trinity2pointO]

@DezLabRD @MattDChrist Yep. Cool concept. Another tool in the box. I’m huge fan of DNP. But got forbid you say that on here without getting crushed.

[THE REAL 💯D👀KS💯 @trinity2pointO]

Nice breakdown and love to hear personal experience. Thanks @MattDChrist 💪🏻

[Matt Christ @MattDChrist]

SANA takes a different approach. Instead of focusing on how many calories you’re eating, it’s designed to increase how many calories your body burns.

[THE REAL 💯D👀KS💯 @trinity2pointO]

@MattDChrist Yessir. Much better safety profile

[THE REAL 💯D👀KS💯 @trinity2pointO]

@MattDChrist This! I’d love to source dinifedriton but it’s just too expensive at this point. Soon, though.

[Crawford Chronicles @CrawfordChron]

@trinity2pointO @labs_vanguard @DigitalFringed1 If yall want to know all the details on the Houston Astros tune in to our podcast

https://t.co/CRPmiDdux5

[THE REAL 💯D👀KS💯 @trinity2pointO]

@CrawfordChron @labs_vanguard @DigitalFringed1 Can I get a mf link 😂

[THE REAL 💯D👀KS💯 @trinity2pointO]

You don’t know about Emodin?

[Elite Research USA @EliteresearchUS]

Emodin is not a single pathway supplement. It is a complete multi-target anthraquinone that simultaneously blocks cortisol regeneration, antagonizes estrogen drive, raises mitochondrial ATP while cutting oxidative damage, and hits anticancer and anti-inflammatory programs most molecules never touch in the same pass.

Before enzyme transcription even enters the picture, emodin selectively shuts down tissue cortisol reactivation, displaces estrogen at the receptor, clears nitric oxide brakes on respiration, and recruits HER-2, HIF-1α, VEGF, MMP, and fibrosis pathways inside one structure.

1. Emodin Starts Upstream: Cortisol Synthesis Blockade and Dual 11β-HSD Control

Emodin's primary stress-hormone target is tissue cortisol regeneration through 11β-hydroxysteroid dehydrogenase type 1, the enzyme that converts inactive cortisone back into active cortisol inside liver and fat.

Selective Nanomolar 11β-HSD1 Inhibition:

Emodin is a potent and selective 11β-HSD1 inhibitor with an IC50 of 186 nM against human 11β-HSD1 (and 86 nM against the mouse enzyme). A single oral dose significantly suppressed 11β-HSD1 activity in liver and fat, reversed prednisone-driven insulin resistance, and improved metabolic readouts including insulin sensitivity, lipid handling, and hepatic gluconeogenic enzymes.

Dual Enzyme Control and Estrogen Antagonism:

Emodin goes further by downregulating 11β-HSD1 expression while raising activity of 11β-HSD2, the enzyme that deactivates cortisol, locking tissue cortisol from both directions at once. It is also a potent estrogen receptor antagonist that displaces estrogen at ER, including ER-α–linked suppression of breast cancer cell proliferation, with inhibitory effects discussed across other estrogen-sensitive cancers including prostate. Relative cortisol excess is a common reason sleep quality collapses after mid life, and reports describe deeper sleep, settled heartbeat, and a relaxed body once that stress tone drops. Cortisol block plus estrogen antagonism is the hormonal background most single-target agents never deliver together.

2. Gut Motility, Mitochondrial Energy, and Anti-Inflammatory Cover

Emodin does not stop at hormone enzymes. It simultaneously supports bowel transit, elevates cellular energy, and calms inflammatory tone at the tissue level.

Colon Motility and Local Inflammation:

Emodin reaching the colon supports bowel movement rhythm, reduces intestinal water over-absorption, and delivers local anti-inflammatory cover exactly where inflamed gut walls impair contractile tone. Digestion reports include smoother elimination, reduced bloating, and visibly improved gut comfort alongside systemic stress-hormone support.

Mitochondrial ATP and Cleaner Respiration:

Emodin increases mitochondrial oxygen consumption and ATP synthesis while decreasing oxidative damage, supports electron transport and NADH recycling back to NAD, and inhibits nitric oxide formation and iNOS so cytochrome oxidase is no longer choked by NO. COX and LOX inhibition add anti-inflammatory metabolic cover on top of the energy lift. Reports of warmer temperature, clearer vision, and higher mood track with that metabolic push.

Endotoxin and Barrier Tone:

Emodin ranks among OTC TLR4 blockers that blunt endotoxin-driven inflammation, reduces vascular leakage, and pairs systemic cortisol control with lower inflammatory drive. Energy up, stress chemistry down: that is the quinone signature.

3. The Anticancer Toolkit That Puts Emodin in a Class of Its Own

Where most anti-inflammatory or cortisol agents stop, emodin recruits HER-2, hypoxia, angiogenesis, invasion, and antifibrotic repair pathways across the same molecule.

HER-2 / Neu Tyrosine Kinase Suppression and Differentiation:

Emodin suppresses HER-2/neu tyrosine kinase autophosphorylation and transphosphorylation, preferentially inhibits growth of HER-2–overexpressing cells, and induces differentiation toward a more orderly, less invasive phenotype.

Hypoxia, Angiogenesis, and Metastatic Invasion:

Under hypoxic inflammatory stress, emodin attenuates COX-2, VEGF, HIF-1α, MMP-1, and MMP-13 at the mRNA level, cutting the hypoxia survival switch, vessel recruitment, and collagenase-driven invasion program in one stroke. Related work links emodin and aloe-emodin to ER-α inhibition in breast cancer models and lower HIF-1α with attenuated cachexia readouts in pancreatic cancer research.

Fatty Acid Synthase, Angiogenesis, and Invasiveness:

Emodin inhibits angiogenesis and invasiveness, blocks fatty acid synthase, and promotes cellular differentiation, collapsing membrane-building and blood-supply pathways aggressive tumors lean on.

Antifibrotic, Antimicrobial, and Systemic Resilience:

Anti-fibrotic studies report reversed fibrosis of heart and liver, with emodin framed as heart protective and as a serotonin antagonist with heart-failure relevance. Broader coverage spans antiviral, antibacterial, and antifungal activity, plus antioxidant, memory-enhancing, and anxiolytic support. One anthraquinone, many disease fronts.

Emodin operates as a complete multi-receptor, multi-enzyme neurometabolic and anticancer anthraquinone by uniting nanomolar 11β-HSD1 cortisol blockade, dual cortisol enzyme control, estrogen antagonism, mitochondrial ATP elevation with lower oxidative damage, nitric oxide and TLR4 cover, gut motility plus colon anti-inflammatory action, HER-2 suppression, HIF-1α / VEGF / MMP attenuation, and antifibrotic systemic repair inside a single molecule.

[THE REAL 💯D👀KS💯 @trinity2pointO]

@DigitalFringed1 @TimothyHopi0l @labs_vanguard Well tis the smell of excellence I cannot argue

[THE REAL 💯D👀KS💯 @trinity2pointO]

@DigitalFringed1 @TimothyHopi0l @labs_vanguard I eat asparagus like every day and tbh I don’t want to smell that shit in a steamy shower especially if I’m tryna get a piece