Tyler Pearson

Currently Postdoc with @levinchem, @group_levin at @UChiChemistry;
PhD with @Freedman_Lab, 2021;
Yale 2015

@tylerpearson.bsky.social

[Tyler Pearson @tyler_j_pearson]

Today it's my pleasure to present my magnum opus from my time in the Levin group: a site-selective benzene-to-pyridine "transmutation"

Now, you can perform C-to-N replacements in arenes with intuitive and predictable site selectivity!

Read all it here: https://t.co/8VX571J8Rb

[Tyler Pearson @tyler_j_pearson]

@awhspeed @chitnislab potassium mirror? one of my favorite setups, but one of my least favorite workups

[Tyler Pearson @tyler_j_pearson]

@JasonKhoury1 the cleanest it will ever be 🥲

[Tyler Pearson @tyler_j_pearson]

@nanobrumberg Oh sure, I definitely don't support the fact that it's freely editable. Hopefully lessons are learned 🤞

[Tyler Pearson @tyler_j_pearson]

Things are getting tense over on the chemistry faculty search status tracker. Stay kind to yourselves!

[Tyler Pearson @tyler_j_pearson]

@ryoma_ous Congratulations Ryoma!

[Tyler Pearson @tyler_j_pearson]

@ndchiappini 5239K24 from McMaster-Carr! It's a bit wider gauge so if you want to do slow additions you'll want something narrower but they have plenty of sizing options. I typically use this for sending reactions into a schlenk filter setup so it needs to be wide enough not to clog.

[Levin Group @group_levin]

@cf_lynch on a column 🧑‍🎄

[The University of Chicago @UChicago]

A chemistry breakthrough could make medication discovery easier. UChicago scientists have created a way to easily replace carbon with nitrogen atoms. Learn more about the studies published in @ScienceMagazine and @Nature: https://t.co/0YIAk3yBGK

[Tyler Pearson @tyler_j_pearson]

See a lovely writeup of our recent C-N exchange reactions in the Levin lab!

@group_levin

[UChicago News @UChicagoNews]

UChicago chemists make breakthrough in drug discovery chemistry https://t.co/YctTqxywCv

[UChicago News @UChicagoNews]

UChicago chemists make breakthrough in drug discovery chemistry https://t.co/YctTqxywCv

[Delius Lab 🇪🇺🇺🇦 @mvdelius]

Our democratically elected #paperofthemonth is @group_levin's impressive study on aromatic nitrogen scanning by nitrene internalization!
https://t.co/pwRhADMbPS

[Tyler Pearson @tyler_j_pearson]

What an honor! Thanks!

[Procter Group @GroupProcter]

#ProcterPOW: Out in @ScienceMagazine the @group_levin from @UChiChemistry report a skeletal editing strategy for nitrogen-scanning; selectively 🔄 an aromatic C - bound to an azide - for N by ipso-selective nitrene internalisation. 🔗👇
https://t.co/JZdz8mxjHZ

[C&EN (Chemical & Engineering News) @cenmag]

Putting a nitrogen in place of carbon in these molecules’ aromatic rings can result in dramatic improvements in key pharmacological parameters—so much so that medicinal chemists have dubbed it the “necessary nitrogen atom.” Read more: https://t.co/S2nM3ZRONu

[UChicago Chemistry @UChiChemistry]

The Levin Group has created a new reaction by swapping a carbon atom with a nitrogen atom in an aromatic ring, which "could make nitrogen scanning much easier."

@LevinChem @UChicagoPSD @UChicagoNews @cenmag @UChiChemistry

[Jonathan L. Kuo @JonathanLKuo]

Don't want to jinx it but... our group submitted our first paper today and I'm super excited about it!! 🎉

Also my first time trying @ChemRxiv
https://t.co/qQuIPZ8hwm

[Dr Bethany Halford @beth_halford]

It was delightful to chat with @LevinChem and @tyler_j_pearson about their aromatic atom swap for my latest in @cenmag.
https://t.co/oiRsTZugZ6

[Tyler Pearson @tyler_j_pearson]

https://t.co/yQfNGDTe55

Check out this awesome write-up by @beth_halford @cenmag about our benzene-to-pyridine transformation!

#chemtwitter

[Tyler Pearson @tyler_j_pearson]

@sasha_sundstrom Lol no the water chiller will be much better. I forgot what you industry folks just have on hand 🙃

[Tyler Pearson @tyler_j_pearson]

@sasha_sundstrom We use those occasionally. I've even stuck two lamps in each side, but you'll want to mount a little PC fan or something on there. Your reaction will get pretty warm without it but it shouldn't be a fire hazard.

[Tyler Pearson @tyler_j_pearson]

Thanks for the excellent write up!

[C2W @Chem2W]

Amerikaanse chemici (@LevinChem) vonden een manier om in een benzeenring een van de C-atomen regioselectief te vervangen door een N-atoom, @ScienceMagazine: https://t.co/RKdkZqE5dI
Also in English: https://t.co/gwuk9saEl4
Met dank aan Jeroen Codée (@LeidenScience @UniLeiden)