Tyler Kaster, MD

#Psychiatry Resident | #UofT | Clinician Scientist Trainee

[The Mental Elf @Mental_Elf]

60 years ago we began using lithium in psychiatry. Countless studies support its efficacy as a mood stabiliser, some even suggest neuroprotective, telomere-preserving & anti-suicidal effects.

BUT #lithium remains under-prescribed. Why?
https://t.co/3QW4Wwc387

[Tyler Kaster, MD @tylerkaster]

Great news for Temerty Centre!

[CAMH Foundation @camhfoundation]

"Brain stimulation treatment has changed my life in so many ways," – Shelley, CAMH Patient. A new $10M donation from the Temerty family means brain stimulation will continue to transform lives for patients like Shelley. Read more: https://t.co/6F9OScKJeV

[Tyler Kaster, MD @tylerkaster]

Highlighting of our work by @BBRFoundation - pubmed link: https://t.co/Qe9nn71M4I

[BBRFoundation @BBRFoundation]

Four distinct response patterns to TMS brain stimulation therapy for refractory major depression point to possibility of individualized treatments. https://t.co/YMC7qzBWzR

#addiction #anxiety #depression #TMS

[ICES @ICESOntario]

Homeless Ontarians discharged from a psychiatric hospital are twice as likely as non-homeless to return to the ED for psychiatric care within a month: recent @ICESOntario @CAMHnews study by @KurdyakP links #housing and #mentalhealth https://t.co/rjlaM7VzoM #housingfirst

[UofTPsychiatry @UofTPsych]

.@BigWhiteWallCA is an online forum for mental health discussions and resources that's available 24/7. @harriet_ek's presentation at the Future of Psychotherapy Conference demonstrates the real impact it's having for those struggling with mental health.

[Psychiatrist.com @PsychiatristCNS]

Computer-assisted cognitive-behavior therapy (CCBT) allows clinicians to deliver care to more patients than would be possible with standard CBT. This meta-analysis sought to determine if additional clinician support can increase the efficacy of CCBT. https://t.co/3MeDVkKsYA

[george davey smith @mendel_random]

Like many I’ve hoped that the observational epidemiological associations suggesting alcohol protected against cardiovascular disease (CVD) were true. Unfortunately, this is not the case, a paper by Iona Millwood, Zhengming Chen, Richard Peto et al shows https://t.co/yKeXqrGqhc

[Journal of Clinical Epidemiology @JClinEpi]

The statistical significance of meta-analyses is frequently fragile: definition of a Fragility Index for meta-analyses https://t.co/K5EURPyxUT

[Tyler Kaster, MD @tylerkaster]

Systematic review of strategies to prevent suicidality in medical students - main takeaway is that there’s not much evidence https://t.co/lxBd3ZYEhK

[Tyler Kaster, MD @tylerkaster]

Attachment theory makes it to @nytimes - who says studying for Royal College exam doesn’t have practical value?

[The New York Times @nytimes]

Here's how to identify your attachment style, and take control of how you manage your time https://t.co/TIsZOyUyW3

[Ken Rothman @ken_rothman]

This illustrates how reliance on statistical significance may be killing people.

[Tyler Kaster, MD @tylerkaster]

Risk of #psychosis with stimulants - small but real. Difference amphetamine vs methylphenidate relevant at population-level but not individual https://t.co/Tm8i39yIB9

[Tyler Kaster, MD @tylerkaster]

Thought-provoking Reuter’s investigation piece on CFS/ME researchers highlights the need for scientists to engage in social media and promote their work https://t.co/jn0oSOlnJq

[Tyler Kaster, MD @tylerkaster]

Despite including studies with a total of more than 14 million participants - predictive validity of models for suicide was extraordinarily low

[Dr Maria Michail 💙 @mariamichail2]

"The performance of suicide prediction models suggests that they offer limited practical utility in predicting suicide mortality." New @JAMAPsych paper out
https://t.co/WWb1KKIuCm

[Temerty Medicine @uoftmedicine]

New study @CAMHnews shows that people with clinical depression have higher levels of a specific brain protein. These findings open the door for potential new treatments. https://t.co/FJ7spFFPcc

[Journal of Clinical Epidemiology @JClinEpi]

Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis https://t.co/U7VyxfW7PA

[Psychiatrist.com @PsychiatristCNS]

Do kids who take second-generation antipsychotics have the same risk of developing type 2 diabetes as adults taking these drugs? https://t.co/pj2PQMoq2I

[Tyler Kaster, MD @tylerkaster]

Today FDA approves esketamine intranasal for resistant depression. First antidepressant since 1980s (!) with nove mechanism of action https://t.co/pWccGuoDCq

[Tyler Kaster, MD @tylerkaster]

Great twitter thread describing how to (and by extension how NOT to) develop and create predictive models

[Frank Harrell @f2harrell]

Clinical trial statistical thought of the day: clinical researchers who truly believe in treatment effect heterogeneity should show their commitment by multiplying sample sizes by 16 (the bare minimum for testing a SINGLE interaction effect).