Tyrcles

BJJ Athlete
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Optimizing health
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n=1
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may be retarded

[Tyrcles @Tyrcles]

@biohacker The days I usually have good mood and clear mind are days I got morning wood

[Bryan Johnson @bryan_johnson]

Salt has been blamed as the culprit for damaging your arteries.

A new mouse study puts salt-sensitive hypertension in context.

Salt doesn't do it directly, it triggers your immune system to do it.

4 weeks on a high-salt diet (8% NaCl) cut vasodilation by over 20% and spiked senescence markers in blood vessel walls. Pure NaCl did nothing to endothelial cells. The immune cytokine IL-16 alone replicated the full damage.

The senolytic (navitoclax) reversed it. Vascular function restored, likely via nitric oxide.

The mechanism behind salt-sensitive hypertension may be the immune response salt provokes, and the senescent cells that response leaves behind.

[Jack @Jackkk]

Bryan Johnson explains why not breaking world records isn’t a failure for the Enhanced Games

“People came into today expecting world records to drop”

“These athletes had a training camp for four months and were only able to enhance for two months. This is a baby step into a new world”

“It’s not a defeat. It’s proof you can enter a protocol with clinical oversight and enhancers in a measured way”

“It is a victory that they’re opening up the possibility that substances can be used in a measured way in sporting events”

[Tyrcles @Tyrcles]

We did see a lot of PBs. For the 50 free I think we would of saw a bigger drop for the guy who set the WR. Seems he had a bit of a hiccup on his start/breakout.

I also thought it was very good we saw a lot of these athletes also fail attempts or miss times. It shows enhancements don't make you this SUPER HUMAN who is magically going to break records and be #1.

Still requires hardwork, great technique, and mentality.

[Tyrcles @Tyrcles]

To be fair that is majorly the "city" and corporate life. I'd argue it's like that in many cities however definitely a bigger issue in Asian countries especially Japan.

However on the flip side of the coin Japan and I also noticed Korea is full of small little coffee shops, restaurants, shops, etc ran by people who've dedicated years to that practice.

Japan is dominated by small businesses and it's beautiful.
In Korea I went to a coffee shop solo ran by a man in his mid 30s. 15 years as a barista and not just some Starbucks barista but a legit one.

Best coffee ever

Two other restaurants in Japan pictured

[Tyrcles @Tyrcles]

@jojeets @0xexpt @PeptidePartners @breakingbagscc @_9th_Life_ I've had immediate responses

The appeal process was easy and stress free

Got full refund

Reordered from a new vendor

Satisfied

[Penguin @BowTiedWaddle]

Should epitalon/Pinealon be considered for pregnancy?

**none of this is medical advice**

Aside from adolescence, gestation is where much of who you are and who you will become is decided. Epigenetics write a script that you are essentially bound to the rest of your life.

Much of your epigenetic makeup is decided by your mom and the environment you’re gestated in. Stress, nutrition, fitness.. and ever increasingly, light environment. 🧵

[Tyrcles @Tyrcles]

@PGC1a_RB 200mg Ubquinol and 100mg ppq in this economy?

Cheaper to buy 🇨🇳peptides

[Tyrcles @Tyrcles]

Takes a little while to notice any effects but wow day and night difference for gut

Like will still get the occasional bad shits and gas but don't get any other symptoms like the ones you mentioned

Fortifies the gut to protect whatever is messing with it from leaking into circulation

[Jamal Dinkoui @BerbarianWizard]

Finasteride doesn’t only lower DHT. It lowers several 5α-reduced steroids.

DHT: strong androgen. Important for libido, erection quality, genital sensitivity, semen volume/quality, penile growth/development, beard/body-hair signaling, and male traits.

3α-androstanediol: DHT-derived brain steroid. Acts on GABA-A. Linked to sexual behavior, calmness, stress response, mood, and arousal.

Androsterone: weak androgen and brain steroid. Linked to calm confidence, androgenic tone, body odor chemistry, and the “masculine scent” signals women may subconsciously read as maturity/androgen status.

5α-androstanedione: 5α-reduced androgen intermediate. Supports the pool of downstream 5α-androgens, including androsterone-related odor steroids.

5α-DHP: 5α-reduced progesterone. Supports allopregnanolone production. Relevant for neurosteroid balance, stress response, sexual behavior, and GABA tone.

Allopregnanolone: major calming brain steroid. Important for mood, sleep, anxiety control, stress tolerance, libido, arousal, and sexual behavior.

DHDOC: 5α-reduced deoxycorticosterone. Supports THDOC production. Relevant for stress-axis neurosteroid signaling.

THDOC: strong calming brain steroid. Important for stress tolerance, sleep quality, anxiety control, and sexual behavior through brain arousal balance.

5α-dihydrocortisol: 5α-reduced cortisol metabolite. Involved in cortisol breakdown and stress-hormone handling.

5α-dihydrocorticosterone: 5α-reduced corticosterone metabolite. Involved in corticosteroid metabolism and stress-response regulation.

5α-androstenol / androstenol-related odor steroids: human body-odor steroids. These may affect how “sexually alive” masculine, warm, or attractive a man smells at close range. Not magic pheromones, but part of the chemical signature in sweat/skin odor that can influence attraction, comfort, and sexual interest subconsciously.

So finasteride is not just “less DHT” It can affect androgenic signaling, brain neurosteroids, libido, erection quality, orgasm quality, genital sensitivity, mood, sleep, stress tolerance, body odor, and the close-range scent signals that can influence sexual attractiveness.

[Tyrcles @Tyrcles]

@user_mm_ @labs_vanguard This dude has raging levels of estrogen.

[𝙷𝚊𝚒𝚋𝚊𝚛𝚊 𝚂𝚝𝚊𝚝𝚒𝚘𝚗 @HaibaraStation]

Kamakura, Japan

[Elijah Krings @Elijahkrings]

B1/2/3 are probably the most important redox vitamins there are

Implementing a targeted therapy where you phase each one of them in and out to modulate redox, detoxification, methylation and immune status might be a good tool to improve base line

B2 at low dosages (5-20mg) at the start, as it ups complex 1 & 2, increases GSH and could potentially provide hypomethylation support (if suspected). Reliefs TCA cycle bottlenecks at succinate dehydrogenase

Phasing in B1 afterwards. This is due to B1 increasing electron flux into the ETC through improved turnover in glycolysis and TCA cycle. Reliefs PDH and a-KG-DH bottlenecks. NADH can now be put into better functioning complex 1 on the ETC, minimizing potential ROS increases at the beginning

Of note, TTFD consumption increases GSH needs, so low GSH and high dose TTFD are not advisable to start with, but rather increasing GSH first. B2 can do that, but also GlyNAC/ Selenium and NRF2 activators

B3 can be phased in if needed to increase NAD partially. High dose protocols should be post boned to somewhat staple phases as it can also backfire. High NAD will turn into NADH and then overload malfunctioning mitochondria

After hearing many stories about how mitochondrial support went haywire and worsened someones conditions, I understood that the purely pushing good redox can backfire if your ETC still cannot handle FADH/NADH as electron donors, due to dysfunctional gas paddles (Vit C/E, CoQ10, Selenium, Zinc, Copper-Iron dynamics, GSH, Catalases)

This phasing should minimize side effects for most. I started doing B2 while on B1, others might crash here

Might be a little theory over kill, for some it might actually work. All depends on the person

[Tyrcles @Tyrcles]

@DocAbirHealth

[Richard @PGC1a_RB]

N=2 (two individuals) reports

One with oral Pinealon, one with injectable Pinealon

You know where you can source injectable, I opt for oral, choose your ROA, though I still lean oral for yet to be studied gut biome into brain axis

[Richard @PGC1a_RB]

"You're not stuck, you're just comfortable in the wrong place"

"Can't keep going back to the same shit and expecting a different smell"

"Can't keep sweeping dirt under the the rug and then wonder why the house feels dusty"

"Sometimes God don't answer because you already know"

[Tyrcles @Tyrcles]

@PGC1a_RB @curtinity @AbudBakri The state @PGC1a_RB usually finds me in

"Okay he's got it"
Me 30 minutes later:

[Tyrcles @Tyrcles]

@PGC1a_RB

[Tyrcles @Tyrcles]

@TheThucydides__ mentioned this to me when discussing pheomelanin and eumelanin phenotypes

Failure of the endogenous antioxidant system is likely the first step toward melanomagenesis

My fellow pheomelaniners beware we are at higher risk due to pheomelanin's higher ROS production

[Noah Ryan @NoahRyanCo]

Spent years close to the equator getting unprotected sun exposure every day: no noticeable photoaging

Get CIRS from toxic mold poisoning (total a-MSH and glutathione depletion): Skin ages 10 years in 6 months, zero sun tolerance.

Endogenous antioxidant activity is everything.

[Noah Ryan @NoahRyanCo]

Spent years close to the equator getting unprotected sun exposure every day: no noticeable photoaging

Get CIRS from toxic mold poisoning (total a-MSH and glutathione depletion): Skin ages 10 years in 6 months, zero sun tolerance.

Endogenous antioxidant activity is everything.