Tywitter

[Nature Biotechnology @NatureBiotech]

For years, the idea of targeted protein degradation stalled because PROTACs were too large and unstable for clinical use. However, in the beginning of May, @US_FDA approved the use of the first PROTAC for adults with a certain form of metastatic breast cancer https://t.co/TJTgn82prd

[Science Immunology @SciImmunology]

A new Science #Immunology study shows that PD-L1 blockade can inhibit MHC-I presentation on tumor cells, enabling immune evasion and #metastasis in mouse models of #pancreatic cancer. @IngunnStromnes https://t.co/CGeW2vgG1K

[Cell @CellCellPress]

In the latest issue! Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections https://t.co/y30oKLvwj2

[Cell Reports @CellReports]

The multifaceted ILC3s: Key regulator of mucosal defense and homeostasis https://t.co/7e13UJ5pwk

[Alex Rives @alexrives]

Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.

We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.

ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.

A world model of protein biology emerges through language modeling.

We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.

The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.

This understanding emerges without prior knowledge, just from language modeling of protein sequences.

Language models are becoming a powerful substrate to understand and program biology.

The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.

I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.

[Tywitter @Tywitter4]

@CmMontauban @_BCT_ @LondonBatGroup @bats_london @UNEP_EUROBATS @BatLifeEurope @batstothefuture @GlobalBatNet @MigrationAnima1 That is one strong, independent female bat

[Pokémon GO @PokemonGoApp]

To help you take on Shadow Mewtwo, we’re giving away codes for Purified Gems if we reach 150k RT! To participate:

Follow us on Twitter
RT this post with #ShadowRaids
Receive confirmation reply

If we reach our target, we’ll send participants a code for Shadow Raid–themed items!

[Global Union of Bat Diversity Networks (GBatNet) @GlobalBatNet]

Our first ever in in-person network leaders meeting is underway!

[Megan Griffiths @Megan3Griffiths]

🔈 New Publication!

(🧵1/6) We are excited to share our new article exploring a #VampireBat betaherpesvirus as a transmissible #vaccine against #rabies, published in @PNASNews!

Read 👉 https://t.co/7bsoOSxOH1
#PNASauthor #CVRBats 🦇

[Global Union of Bat Diversity Networks (GBatNet) @GlobalBatNet]

RSVP for our inaugural "My Field for Dummies" webinar on Microbiome research with @bat_biomes is now open via the event link! We will be sending the Zoom link via the RSVP, so please register!

Feb 22 @ 9 AM New York | 2 PM London | 9 PM Bangkok

https://t.co/WJ6EIs9PIS

[Kristen Panthagani, MD, PhD @kmpanthagani]

Florida just announced the results of an analysis that they performed, saying the results show "an increased risk of cardiac-related death among men 18-39" for the mRNA vaccines, and recommend this group not receive these vaccines.

Is this justified? Let's look at the data...

[Sorek Lab @SorekLab]

Happy to see our paper out @nature:

Phages confiscate signaling molecules produced by immune TIR proteins to cancel host immunity

Structure of anti-defense "sponge" protein reveals a new class of antiviral signaling molecules: glycocyclic-ADPR (gcADPR)

https://t.co/kvKixqqi3z

[Massimo @Rainmaker1973]

The platypus localises its prey using almost 40,000 electroreceptors arranged in front-to-back stripes along its bill.

Bonus: this is sound it makes

[read more: https://t.co/3rRiT9fy7f]
[📹 Platypus Conservation Initiative]

[Tywitter @Tywitter4]

@Mohamad_IPS That’s exactly what happened to me as early on as applying for a research job or other jobs right after my master’s!

[Sanna Madan @SannaMadan]

How do immune cells stop themselves from aging & stay young?

Turns out T cells can acquire telomerase from antigen-presenting cells and escape senescence!

Fascinating new anti-aging mechanism used by the immune system for long-lasting protection
https://t.co/qfAHu8yMlU

[Bat Researcher - PRS Aaron Irving @BatResearch]

Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial #oralvaccines https://t.co/fwBt5G15pV

[Bats Nightly 🇵🇸 @BatsDaily]

THEY LOOK LIKE TINY COTTON BALL PIGGIES AND I MEAN THAT IN THE NICEST WAY POSSIBLE I LOVE THEM!! 🥰🦇

[Bats Nightly 🇵🇸 @BatsDaily]

an actual angel appears!! 👼🦇

[Bats Nightly 🇵🇸 @BatsDaily]

these photos were taken by Jakob Fahr who has taken many more amazing pics of different animals.
i feel horrible for not crediting sooner so please check out Jakob's work if you have the time!!