Excited to share work from my thesis that was just preprinted! We learned new things about PML, TREX1 and the novel “Plex9” genes by studying homologs from fish 🐟. This was only possible with the help of so many wonderful collaborators!
https://t.co/CCFu21k8PY
1/4 Our @biorxivpreprint, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells can uniquely tolerate EWSR1::FLI1 expression, leading to tumor formation in vivo. A big thanks to our collaborators @clairearataphd and @CrumpLab for this adventurous journey! #NeuralCrest #cancer #EwingSarcoma #zebrafish @amatrudalab @ChildrensLA@biorxiv_cancer👉https://t.co/h0QP0FgX5n
So excited to announce that I am going to start my research lab at UT southwestern on January 2025, to study cancer cell state dynamics and epigenetics! Currently recruiting postdocs, research technicians among others! Check out my lab website with the QR code for more info!
Super excited to share this preprint of our study uncovering a novel PRP4K - CHMP4B / Vps32 splicing circuit regulating autophagy that is conserved over 600 million yrs of evolution between amoebae & humans, funded by @CIHR@NSERC_CRSNG#Tweetorial 1/10 https://t.co/FFeqsWtWUr
Our vitamin C paper has now been peer reviewed! Once Kevin left our lab, finishing this relied on a fantastic team effort that I'm quite proud of.
And it has made us wonder how else metabolites affect TE biology.
https://t.co/OZdnkrda1U
Another interesting paper in Nature... applying spatial localization constraints on biomolecular networks - a lot of modelling and math but pretty relevant I would think for understanding nuclear body function. Check it out @u_me_evolution https://t.co/ZwT82cTSbC
See in #ScienceAdvances our new @Hydra monster where tentacles get transformed to feet when the transcription factor Zic4 that promotes tentacle formation and prevents epithelial transdifferentiation is down-regulated! https://t.co/bbmZ9X9Hpy
Nice and informative biographical sketch from my PhD supervisor Martin Embley: "It Took Me a While to Figure out What Science I Really Wanted to Do" https://t.co/lH2R68rysn
@ThePhDPlace So lucky to have @DocDellaire as my supervisor. I get to work on such fun projects for my PhD. I’m grateful he provides a space to explore cool random ideas. Hes helped foster a constant excitement for science for the rest of my career!
Unlike most animals, #Hydractinia embryos do not complete gastrulation, carrying forward a population of embryonic-like #stemcells (aka i-cells) into adulthood. @VarleyAine et al show that an adult animal – soma and germline – can derive from one i-cell
https://t.co/OnG8reeAfE
Oh dang! Our new manuscript looking at retina neurogenesis in squid is out today in @CurrentBiology. Congratulations to co-first authors Francesca Napoli and Christina Daly and the rest of the lab who contributed! @Kyle_Mac1
https://t.co/YdmTUUQV9N