Hitoshi Sawa (En)

Professor at NIG. Studying cell polarity and asymmetric division using C. elegans. Moving to Japanese account @dpynonunc

[eLife - the journal @eLife]

Three Wnt signalling proteins help to organise cells in the gonads of a nematode worm.
https://t.co/lUEyDNpoZr

[Hitoshi Sawa (En) @uncNondpy]

I will be moving to https://t.co/4QDkAnYQze 😃

[国立遺伝学研究所 @NIG_idenken]

Sawa group has published a wonderful paper entitled "Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad” in eLife !
https://t.co/8TyUgtZXpA

[Hitoshi Sawa (En) @uncNondpy]

@eLife Although the pushing mechanism is important, we also show that DTC (no filopodia/lamellipodia) can self-migrate, since, in the triple mutants, Z1 derived DTC pass through germ cells to migrate posteriorly. Also DTCs in germless mutants can migrate.

Eppur si muove!

[Hitoshi Sawa (En) @uncNondpy]

Published😃
https://t.co/icgYewuRlS

[Hitoshi Sawa (En) @uncNondpy]

The gonad of C. elegans has mirror-symmetric structure with DTCs migrating distally (anteriorly and posteriorly). We found that this mirror-symmetry is regulated by distinct functions of three Wnt proteins and Wnt-independent lin-17/Fzd function.
https://t.co/LuUHfQ0Ja2

[Hitoshi Sawa (En) @uncNondpy]

@eLife Therefore, placing DTCs through asymmetric divisions at the distal ends ensure their distal migration, probably through pushing mechanism by germ cells as shown.
https://t.co/agnCVMTOhF

[Hitoshi Sawa (En) @uncNondpy]

The end of October, still no snow. It is really unusual.🎃

[Hitoshi Sawa (En) @uncNondpy]

Mt. Fuji, at the end of summer/start of autumn. (negative control of snow fall)

[Hitoshi Sawa (En) @uncNondpy]

Striped Mt. Fuji🥰

[Hitoshi Sawa (En) @uncNondpy]

Congratulation for Gary and Victor for Nobel prize🎉🎊🎖️

[Hitoshi Sawa (En) @uncNondpy]

Thank you very much for appreciation of our work!

[Review Commons @ReviewCommons]

Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad

@uncNondpy

https://t.co/hRt1H7vBB8

[Hitoshi Sawa (En) @uncNondpy]

@plaschka_lab @mvorland @patricia_rothe @justuskleifeld Congratulation for the fantastic work🎉🎉 It has been s---o long, since I showed requirements of protein factors and ATP for spliceosome disassembly.
https://t.co/VOaL5uLvFK

[Hitoshi Sawa (En) @uncNondpy]

Recently it was shown that DTC is not self-migratory but pushed by proliferating germ cells. However, since mis-positioned DTC migrates posteriorly passing through germ cells, and DTCs in germless mutants can migrate, our results suggest self-migratory ability of DTCs.

[Hitoshi Sawa (En) @uncNondpy]

The gonad of C. elegans has mirror-symmetric structure with DTCs migrating distally (anteriorly and posteriorly). We found that this mirror-symmetry is regulated by distinct functions of three Wnt proteins and Wnt-independent lin-17/Fzd function.
https://t.co/LuUHfQ0Ja2

[Hitoshi Sawa (En) @uncNondpy]

In lin-17 egl-20 cwn-2 mutant, both Z1 and Z4 have the same polarity orientation resulting in abnormal position of Z1-derived DTC, not at the distal end of gonad. This leads to its miss-migration posteriorly, disrupting mirror-symmetric gonadal structure.

[Hitoshi Sawa (En) @uncNondpy]

I was glad to see former intern student @Ankita_13Jha and heard her exciting talk about BLEB! Hope continuation of your successful career!

[Ankita Jha @Ankita_13Jha]

It was soo fun to meet @uncNondpy ☺️ after some 10 years or so!! I was a little science baby when I did a summer rotation in Japan.

[Hitoshi Sawa (En) @uncNondpy]

Evacuation by fire alarm at the conference. (Not serious)

[Hitoshi Sawa (En) @uncNondpy]

I will fly HND-HKG-BOS for 25hrs to attend https://t.co/3XzqfEXgOo