@daveclarkemd Very helpful and insightful
Psychosocial aspects and lifestyle medicine
The Immune Mind by Monty Lyman is a great read about immunopsychology etc
Was eye opening
@hjluks The effect of exercise muscle immune modulation is fascinating.
Sluka’s et al work on exercise (both aerobic and strength) effect on M1 and M2 macrophahes is exciting
@PhysioMeScience 👍🏻 As stated, it’s important not to overstate the effect size of exercise on pain…
having said that, exercise is one of the best ways to improve overall health including metabolic and immune
@adamdobson123 @DrMarwanAl_D Mazza DF, Boutin RD, Chaudhari AJ. Assessment of Myofascial Trigger Points via Imaging: A Systematic Review. Am J Phys Med Rehabil. 2021;100(10):1003–1014.
PMCID: PMC8448923
@PhysioMeScience Interesting test and paper… commendable 👍🏻
Suspect a significant % of cohort would not be able to perform… interesting to know how many were excluded in the trial due to inability to perform?
@PhysioMeScience With the added caveat that the effect size on pain from exercise wasn’t outstanding and that “sham” (albeit hard to define non-specific exercises as sham) had similar outcomes to specific tendon targeted exercises.
Patient expectations and beliefs play a significant role.
@BrandonLuuMD Om3 EPA & DHA play an important role in inflammation resolution from M1 to M2 states
Resolvins, protectins and maresins
Not surprisingly they show up in these studies with positive influence
However study design is hard connect causation as you eloquently said
New study finds evidence for neuroinflammation in the periphery of individuals after WHIPLASH. Very well conducted study! Sample size ✅ control group ✅ Sig. findings on MRI ✅ Sig. findings on blood tests ✅ Sig. findings on QST ✅
Seriously, the notions of “brain derived pain” without nociceptive input pain are just plain nonsense and not sustainable anymore.