Medical college:
"Just pass the exams."
NEET PG:
"Remember every line you've forgotten since first year."
Who else feels personally targeted by this system? 🙋♂️
#MedX#MedEd#NEETPG#Aspirants#MedTwitter
A lot of people struggle with Biochem and trying to rote memorize in which state is enzyme activated and in which state is it deactivated.
There is simple way to remember.
As far as regulation is concerned - if you’re moving away from glucose - enzymes are active in dePO4rylated state and when you’re moving towards glucose - in phosphorylated state.
So Glycolysis - dePO4
Gluconeogenesis- PO4.
Glycogen synthesis - dePO4
Glycogenolysis - PO4
The logic is pretty neat.
When you’re doing Glycolysis - the goal is to make ATP. When the goal is to make ATP - why do you want to waste that ATP to phosphorylate the enzymes? So enzymes have to be activated in Dephosphorylated state.
Opposite for Gluconeogenesis/Glycogenolysis.
Cell has ATP. Now during fasting state - it’s using that ATP to make glucose. Hence enzymes are active in phosphorylated state.
A lot of people preparing for NEET PG have issues remembering which disease is autosomal recessive, what is dominant.
While ofcourse - at the end of the day it is a little bit of rote memorisation - there is a certain logic to it.
Remember- enzymes- pretty much of all them in our body are more than what’s required.
So, even a 50% enzyme activity suffices for majority.
Hence, unless enzymes are fully zero - disease won’t manifest.
So, any enzyme deficiency- will be AR - both genes have to be mutated/absent.
PKU
Galactosemia
Glycogen storage disorders
Congenital adrenal hyperplasia
Alpha 1 anti trypsin
Wilson
Even 1/2 Hb causes mild anemia - so even That/Sickle cell are AR.
Contrast this with neuromuscular damage in general.
Anything that causes damage to nerves and Muscle- even 50% damage would result in disease.
If you look at AD diseases - most are have some issues either with nerves or muscles or cytoskeleton.
Huntington
Myotonic dystrophy
Achondroplasia
Marfan
Hypertrophic cardiomyopathy.
Most neurocutaneous syndromes. (tuberous sclerosis/neurofibromatosis)
Ofcourse this is not hard and fast.
But serves to improve your memory and understanding.
X linked is genuinely just rote memorization. Those genes just happened to be on X chromosome.
🚨 HEATED ARGUMENTS BETWEEN VIRAT KOHLI AND TRAVIS HEAD 🚨
🔺During Shivang’s over, Virat Kohli sledged Travis Head while Head was fielding or not batting yet.
🔺Kohli said 🗣️: “Come bowl some overs now.”
🔺Shortly after, Virat Kohli got out.
🔺Travis Head then clapped back and said 🗣️: “Mate, you got out before I even came on to bowl.”
#SRHvsRCB
Never Slept on roads
Never licked others feet
Never used religion for votes
Never used women card
Never married 3tyms
Never used caste for votes
Never merged with the one who scolded their mother
LEADER @TVKVijayHQ 🔥
🚨 CAPTAIN PAT CUMMINS IS BACK 🚨
- Pat Cummins returns to lead Sunrisers Hyderabad, replacing Ishan Kishan as captain for the ongoing season of IPL 2026.