Anastasiia

MD, Pathologist

[C. Christofer Juhlin @DrJuhlin]

In thyroid cancer, skeletal muscle invasion represents extrathyroidal spread, but this is only reliable in the lateral lobes and not the isthmus. This is due to Soemmerring's muscle arising from the hyoid bone and inserting on the isthmus. Be careful when assessing tumors here!

[Silvija Gottesman MD @SGottesmanMD]

Nodal nevus in the capsule vs Melanoma Metastasis (subcapsular). Same patient. Nice contrast in cellular morphology and IHC #dermpath #pathology #IHCpath

[Nadia Hameed, MD @NadiaUSAMC]

Pilomatrix-like High Grade endometrioid Adenocarcinoma of the ovary
1. Basaloid nests
2. Necrosis
3. Abrupt keratinization
4. Ghost “ shadow” cells

[Raza Hoda, MD @RazaHoda]

Case of Apocrine Encapsulated Papillary Carcinoma (EPC)🔬

A vanishingly rare entity—fewer than 10 cases reported. This apocrine EPC lacks myoepithelial cells and is ER-negative, yet remains staged as pTis.

#PathX #PathTwitter #breastpath

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Esophageal biopsy showing sebaceous heterotopia for a Wednesday! #UMiamiPath

[Rafael de Deus @rafaeldmoura]

A young adult presented with multiple erythematous to violaceous plaques on the extremities.

💡 Take a look at the histopathology — what is your diagnosis?🔮🔬

[Ziad El-Zaatari @ziad_zaatari]

🔬🧑‍🏫 Lessons in Pathology: The reason why we submit the appendix tip in appendectomy specimens... Sometimes you will find a neuroendocrine tumor, like in this case!

So always look carefully and don't forget!
#GIpath #Pathology #PathologyBasics

[Steven @STEVENKOLKERMD]

A blob of dystrophic calcification within a nevus. If Nanta can do it with bone, I think I do it with this calcification. I will call it Nevus of Kolker

[Toby Schmitt, MD @TobyASchmitt]

BAP1-inactivated melanocytoma:
- Large epithelioid melanocytes with distinct cytoplasmic borders
- Symmetrical and tends to show maturation with depth
- Loss of nuclear BAP1 staining

Whole slide image and more info at: https://t.co/toL8thD0go

[Leonie Beauchamp, MD @LBeauchampMD]

You’re reviewing a testicular orchiectomy specimen and come across a scar.

What’s on your differential diagnosis?
#GUPath #PathTwitter #MedEd

[Silvia Carino @oralpathologyok]

Adenoid Cystic Carcinoma. Micro Tips. #salivarygland#salivaryglandtumors#oralpath💓

[Janira Navarro @Janiranavarro]

Pleomorphic adenoma-the ultimate borderland 1/2
Avoid missing a myoepithelial carcinoma/myoepithelial carcinoma ex PA

Clues (for myoepithelial carcinoma)
-Uniform myoepithelial proliferation (pic 2)
-Expansile lobulated growth (pic 3)
-Zonal distribution of hypercellular and hypocellular regions

Dr. Sajed #USCAP25 #pathology #PathX

[Raza Hoda, MD @RazaHoda]

Case of Carcinoma with Apocrine Differentiation 🔬

This special type shows tumor cells with prominent nucleoli and abundant granular eosinophilic cytoplasm. Molecularly, this carcinoma is characterized by AR upregulation without ER activation.

#PathX #PathTwitter #breastpath

[Raza Hoda, MD @RazaHoda]

Let’s review HER2 immunohistochemistry this week!

Case of HER2 Null 🔬

HER2 Null cases show complete absence of membranous staining.

Be sure to check out my @captodayonline HER2 webinar Tuesday June 10th. Register here: https://t.co/MZVZSBRDjT

#PathX #PathTwitter #breastpath

[Ankur Sangoi @slusagar]

70 y/o with dysuria, cystoscopy shows red patches

▶️#beautyinb9 #GUpath follicular cystitis

top DDx is follicular lymphoma

[Janira Navarro @Janiranavarro]

Oral epithelial dysplasia
WHO-2022: 3-tiered grading system
Defining dysplasia grade only in this manner oversimplifies the complexity of grading

Cytological atypia confined to the basal third may be sufficient for a diagnosis of severe dysplasia, depending on individual features present, particularly bulbous rete processes, budding and disorganization of basal cells, and marked pleomorphism

Pics Credit: Dr. Hernandez-Prera #USCAP25 #pathology #PathX

[Janira Navarro @Janiranavarro]

Breast-Challenges in diagnosis
Case diagnosed as invasive lobular carcinoma due to negativity for ecadherin
This lesion was also triple negative and CK negative
Patient had history of plasma cell neoplasm
Lambda stains were positive
Final diagnosis: metastasis of a plasma cell neoplasm

Dr. Sahin #USCAP25 #pathology #PathX

[Lorand Kis @kis_lorand]

Let me contribute to the "big specimens' season" with (literally) an orange in the uterus 😀😀 The bonus questions are:
1. what was the preoperative diagnosis in the endometrial biopsy?
2. what did the pathologist do after seeing the biopsy?
#pathology #gynpath

[aung phyo @pathphyo]

80 years old man with ulcerated lesion on hard palate. H&E sections reveal infiltrating pleomorphic tumor cells with rhabdoid morphology and sarcomatous appearanc.IHC came out positive staining for Pan CK, CK 5/6, p40, INI 1 and negative staining for desmin, myogenin and S 100.

[Abhijit Das, MD @AbhijitSurgPath]

Kidney tumors - updates & newer entities (Basic facts for residents)

Molecularly defined entities involving TFE3, TFEB, ELOC, ALK, SMARCB1, SDH, FH etc. Evolving classification of papillary renal cell carcinoma.

#MakeSurgiPathEasy
#RenalTumorsUpdates