You Kaiqiang

Post doc at Beijing Cancer Hospital. Amateur programmer. Bioinformatics PhD @PKU1998.

[You Kaiqiang @vagaryplay]

@yetone 有必要从 cpa 迁移过来不

[You Kaiqiang @vagaryplay]

@Kaili_Fan Congras ! Is this resource available for now ?

[You Kaiqiang @vagaryplay]

@ZhengyangG51844 @NatureCellBio 祝贺🥳！

[You Kaiqiang @vagaryplay]

@araseb_ 这是个冷笑话吗🥶

[You Kaiqiang @vagaryplay]

@Bitita15 我关注你了！

[You Kaiqiang @vagaryplay]

Got tired of limescale and hard water ruining my skin/hair, I DIYed an inline ion-exchange resin softening setup for my showerhead. Hardness dropped from 1000 down to 0–25 ppm. Only cost me <$20 + one hour, 100% renter-friendly. Let me know if you want a guide + parts list! 🚿🧪

[You Kaiqiang @vagaryplay]

@istdrc 严肃关注！

[You Kaiqiang @vagaryplay]

@OneTriangleAI it seems the cache hit rate are alway 0%

[Prof. Nikolai Slavov @slavov_n]

Is single nucleus RNA-seq representative of single-cell transcriptomes and proteomes ?

This comparison shows that:
1⃣ Both scRNA-seq and snRNA-seq correlate weakly to single-cell proteomes.
2⃣ The correlation is much lower for snRNA-seq

1/

[Prof. Nikolai Slavov @slavov_n]

Our article is in today's issue of Nature.

It shows that our proteome is more diverse than we thought, remarkably so !

This has been a long and exhilarating journey beginning in 2019. It has opened perspectives that we are very eager to explore. https://t.co/6bWeQY987Z

[You Kaiqiang @vagaryplay]

@guoxudong_ @wey_gu @NowledgeMem 那我也要把我放养的也调整一下了

[You Kaiqiang @vagaryplay]

@istdrc we are getting out of avatar!

[You Kaiqiang @vagaryplay]

have been extensively playing with raft. the process is so smooth that i am now addicted now. spend hours and hours with my agents (now 6 but i think more would come) to get things done

[stdrc @istdrc]

Hi, I'm RC. I built Kimi CLI at Moonshot last year, and back in 2015, bots that lived in group chats. For the past four months, I've been building Raft in public.

Today I'm launching Raft 1.0.

Right now, working with agents means juggling terminals, sessions, and skills. The more you run, the more you end up holding it all together yourself, and the easier it is to lose the thread.

Raft puts your agents in team mode: one workspace where working with agents feels like messaging your team. The work keeps moving, and you stay at the wheel.

Meet my Raft agent team👇

[You Kaiqiang @vagaryplay]

@mattpocockuk cant wait to see it !

[You Kaiqiang @vagaryplay]

@AubreyZ1120 have you tried agents like openclaw or hermes?

[You Kaiqiang @vagaryplay]

@wey_gu 恭喜古老师！

[You Kaiqiang @vagaryplay]

@istdrc 🥳🥳🥳

[Peter Koo @pkoo562]

Anatomy of BioML papers:

1. create benchmark misaligned w/ REAL biological goals

2. develop ML model w/ jargon-maxxing

3. compare vs models that are inappropriate or out of context

4. give it hypiest name — foundation model 3 years ago; virtual cell last year; world model now

[Hou Chao @houchao1]

🚨 Our paper of explaining why larger pLMs do NOT always perform better on fitness/variant-effect prediction was published.

See our previous thread for the key insights, and check out the paper for the full story.

[You Kaiqiang @vagaryplay]

@ianghunk @jakevin7 我现在的流程就是用 /grill 系列代替plan，如果是轻一点的任务，就直接实现，稍微复杂点的，接 /to-spec 和 /to-ticket，然后就能全交给ai挨个解决了。不过一开始可能需要set-up一下，可以看看matt的视频，还是挺清楚的。