Victor Angel

biobanker, designer

[Victor Angel @vanmosti]

@m_goes_distance Or the complementary interventions to counteract side effects

[Victor Angel @vanmosti]

@shelbynewsad Idk.. I think inference will do a lot of the heavy lifting once encoders across modalities get good enough. I find it more likely that H&E (soon unstained tissue) will take over NGS/st/sp for majority of cases

[Victor Angel @vanmosti]

@jontycorrin @wildtypehuman Biobanks with automated data gen for the win

[Victor Angel @vanmosti]

@treejordan Worst part is they weren’t QR codes

[Victor Angel @vanmosti]

MRD is the oura ring of cancer care

[Victor Angel @vanmosti]

@nathanbenaich @vivnat @GoogleDeepMind @raais Scientific discovery will go the way of vinyl

[Victor Angel @vanmosti]

@ServerSock @braelyn_ai + Nikola trucks

[Victor Angel @vanmosti]

Anyone building models for adaptive therapies, akin to pest control, but for cancer?

[Victor Angel @vanmosti]

@m_goes_distance Biobanks are due for an upgrade. From static sample repositories to dynamic data factories,

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

most "AI for biology" startups aren't AI companies

they're data companies wearing an AI costume

the Protein Data Bank cost roughly $20B to build and OpenFold matched AlphaFold's performance on 1% of it

that tells you the model was never the scarce resource

the moat is whoever owns the weird, expensive, impossible-to-copy dataset nobody else can generate

if you're investing in this space, 2 things:

1) stop asking founders about their model architecture, start asking what data nobody else has
2) DM me

[Victor Angel @vanmosti]

@shelbynewsad Operate with integrity.

[Victor Angel @vanmosti]

@claudiosgbjj ie the Venetian glassmakers who made clear glass for the first time. They inadvertently spurred centuries of optics innovation, catalyzing advances in biology, chemistry, astronomy, medicine, art, and even AI (via optical lithography for GPU fabrication)

[William A. Wallace, Ph.D. @WilliamWallace]

The gut-brain axis is a bidirectional communication network between the gastrointestinal tract and the central nervous system. This dynamic system integrates neural, endocrine, immune, and metabolic signals, many of which are modulated by the gut microbiota.

🧠 1. Neural Pathway
The vagus nerve and enteric nervous system (ENS) transmit afferent signals from the gut to the brain. Microbial metabolites and host-derived neurotransmitters (e.g., serotonin, dopamine, GABA) influence mood, cognition, and stress responses. Enteroendocrine and enterochromaffin cells release neuroactive compounds in response to microbial cues.

🧬 2. Endocrine Pathway
The gut microbiota modulates HPA axis activity through changes in gut barrier integrity, circulating metabolites, and stress hormones. Cortisol, released from the adrenal cortex, affects both systemic inflammation and brain function. Microbiota-regulated hormones such as GLP-1, CCK, and ghrelin further influence appetite, mood, and behavior.

🦠 3. Immune Pathway
Microbial antigens (PAMPs) and metabolites interact with intestinal immune cells (e.g., Th1, Th17, dendritic cells), influencing systemic and neuroinflammatory tone. Elevated cytokines like TNF-α, IL-1, and IL-6 have been linked to blood-brain barrier disruption, depression, and cognitive impairment.

🔁 4. Metabolic Pathway
The gut microbiota ferments dietary components (e.g., fiber, protein, bile acids) into signaling molecules including:

-SCFAs (butyrate, propionate)
-Secondary bile acids
-Branched-chain amino acids (BCAAs)

These metabolites affect energy regulation, neurotransmission, and epigenetic signaling within the CNS and peripheral tissues.

[Victor Angel @vanmosti]

@SynBio1 Isn’t this how the MIT media lab is financed?

[Victor Angel @vanmosti]

Data will soon be the most important asset class

[Kyle Tretina, Ph.D. @AllThingsApx]

BioAI hit a data wall 🧱BaseData tries to shatter it 💥

9.8 B 🧬 protein sequences + >1 M 🦠 unseen species, gathered with enforceable benefit-sharing 🤝, expand known diversity >10× 🌍

Next-gen bio-FMs just got rocket fuel 🚀

[Kyle Tretina, Ph.D. @AllThingsApx]

BioAI hit a data wall 🧱BaseData tries to shatter it 💥

9.8 B 🧬 protein sequences + >1 M 🦠 unseen species, gathered with enforceable benefit-sharing 🤝, expand known diversity >10× 🌍

Next-gen bio-FMs just got rocket fuel 🚀

[Victor Angel @vanmosti]

@NWischoff This is why VC as an art is dying. Focus on chasing markups instead of building amazing companies.

[Victor Angel @vanmosti]

@wolfejosh @Osmo_Labs Reminds me of a Robin Williams film where he would "edit" a highlight reel from people's lifelong recordings to play it at their funeral

[Simona Cristea @simocristea]

The human body never ceases to amaze

[Victor Angel @vanmosti]

I wonder how well these benchmarks generalize across health systems

[Matthew Berman @MatthewBerman]

What if you had a world-class doctor in your pocket, 24/7, at no cost? That’s the promise of AI in healthcare, but mistakes can be catastrophic.

That's why OpenAI launched HealthBench, a new benchmark to test how well AI models handle real, complex medical conversations.

Here's what you need to know 👇