Today marks an important milestone for @moderna_tx , for the field of mRNA, and for the many people working to bring new possibilities to patients.
This morning, Moderna and Merck announced positive Phase 3 results for adjuvant treatment with intismeran autogene, an individualized mRNA therapy for melanoma, in combination with KEYTRUDA, in patients with completely resected stage IIB-IV melanoma. The study met its primary endpoint of recurrence-free survival and a key secondary endpoint of distant metastasis-free survival.
This is the first positive Phase 3 result for an individualized neoantigen therapy, and the first for an mRNA-based cancer therapy.
When we founded Moderna in 2010, the idea that mRNA could become a new class of medicines was outright rejected. The idea that we might use it to create a therapy designed around the unique mutations in an individual patientโs tumor was even further from reality.
Todayโs result is a reminder of what can emerge from pioneering: asking questions others have not yet asked, following the science where it leads, and persevering through uncertainty.
There is important work still ahead but today is a moment to recognize the extraordinary work behind this milestone.
Congratulations to the entire Moderna team, our partners at Merck, and the investigators who made this study possible. Most importantly, my gratitude goes to the patients and families whose participation enables progress like this.
Proud of this milestone, and of everyone who helped bring us here.
@CAgovernor btw, where is the promised high-speed rail you have been building for the last 200 years? Maybe it is better to stop government corruption first?
@NYCMayor How about you stop wasting PPls money?
We all know the story: Try to stay in your position as long as you can, 10x your bank account, and finally leave without fulfilling any of your promises, blaming others for it.
If you feel lost, build something.
A business. Your body. A skill set. Anything that gives you a reason to learn and focus.
Don't worry about choosing the right thing. Don't think about how difficult it will be.
Just start moving forward and you'll find a path that feels right