Dra. Alejandra Babini | Embajadora del Congreso PANLAR 2021 • "Estamos convencidos que va a hacer un congreso muy interesante en el que van a estar contentos de haber participado"
News Feature: FDA Panel Rejects Tanezumab for Osteoarthritis
A 2 day FDA review by the Drug Safety and Risk Management and Arthritis Advisory Committees has yielded a 19-1 vote against the approval of tanezumab for use in OA.
https://t.co/ltKmm9Nl1y
Small study of 25 pregnancies in RA compared those who continued biologics till conception vs those who stopped before conception. Continuing biologics till conception lead to a significantly shorter time to pregnancy. https://t.co/x9EptzkvYr
Systematic review of Paternal DMARD exposure prior to pregnancy shows no firm evidence of harm with TNFi, ABA, RTX, azathioprine, cyclosporine, HCQ, leflunomide, MTX or mycophenolate mofetil. Data from 84 papers, 611 male exposures, 5986 pregnancies https://t.co/VgEsrXhfdh
Metanalysis of 11 RCTs (1353 patients) shows that saline injections are as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain https://t.co/z7jhOSUwQU
Sanofi suspended Kevzara (sarilumab; 200 or 400 mg) studies in severe hospitalized COVID-19 infx - phase 3 trials didnt meet primary or secondary endpoints vs PBO. 420-Pt multinational trial had similar SAE and death rates in all 3 arms https://t.co/YkuKnVm9B8
Comparative retrospective study of 251 ANCA+ pts with AAV (MPA or GPA) & severe renal Dz induction Rx with CYC or RTX, +/- PLEX. Remission equally achieved by CTX or RTX; addition of PLEX did not change outcomes. Predictors ESKD and death - eGFR <15 https://t.co/2lbGUS1ahv
President Trump took HCQ/Azithromycin.... Lancet Rheumatology reports that HCQ in RA has no cardiac risk but long term HCQ increases risk cardiovascular mortality, that may be further augmented by azithromycin. https://t.co/JRtkkAuEeu
OPINIÓN: cuando Brandoni era mano derecha de Alfonsín, Aníbal Fernández iba detrás de Luder que apoyaba la autoamnistía militar o detrás de Menem cuando indultaron a los genocidas. Por Alejandro Borensztein https://t.co/ZgSEPVfbVa
Mayo clinic: Theres a delay in diagnosing Seronegative RA - 1st joint swelling to diagnosis of RA was 187 days for seroneg vs 11 days for seropositive patients (P<.001). Seronegative RA less likely to achieve remission (28% vs 50% at 5 years) (P=.007) https://t.co/Hgewjmt1CL