Happy to share the LTFU data from VIALE-A Phase III trial for Newly diagnosed AML unfit for induction. With 43.2 months follow up median OS 14.7m with Venetoclax/Azacitidine. Details of dosing adjustments in patients on therapy >6 cycles included. https://t.co/wN89ZybVvB
Promising early outcomes with Spanish academic CAR T in non-Hodgkin lymphoma 👏 @BrJHaem
- 3 year PFS 40%, OS 52% 👀 (small numbers)
- ORR 73%, DOR 56% @ 3yr
- ⬆️LDH assoc worse PFS
- 4% Gr≥3 CRS, 2% Gr≥3 ICANS
https://t.co/It1A5XdsvM
@JulioDelgadoHem@Manel_JuanOtero
Access is key in CAR T!
New: Final results from the phase 3 HOVON/SAKK trial, comparing R-CODOX-M/R-IVAC versus DA-EPOCH-R in patients with newly diagnosed Burkitt lymphoma
https://t.co/74MH7fEAn6
#ASH23 abstracts out! Here is a highlight:
Check out this from the FLAIR @NCRI_partners trial
MRD-directed Rx length of Ibr+Ven vs FCR phase III RCT
Massive PFS adv + OS benefit for Ibr-Ven #CLL#lymsm
Congrats to all UK investigators, Tal M and Pete H.
https://t.co/PfXlhbcwZR
100% agree! This is an example of how trying to recommend a drug based on marginal data in an indication where other more promising drugs should be studied & could be better such as menin inhibitors
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PRESENTATION ID S229 PROPHYLACTIC EFFICACY OF INTRATHECAL VERSUS INTRAVENOUS METHOTREXATE FOR CNS RELAPSE IN HIGH-RISK DIFFUSE LARGE B CELL LYMPHOMA : A PHASE III RANDOMIZED, CONTROLLED STUDY #EHA23#lymsm
Credit to #Seung-AhYahng& 🇰🇷 colleagues for #CNS Prophylaxis Randomised study👏
Reminder of delay #3 #R-CHOP if intercalate HD-MTX.
Any efficacy in either?
Having moved to discussing EOT HD-MTX in ‘high-risk’ pts recent data challenging that!
Moving to baseline imaging/CSF #EHA23