What if we’ve been overdosing immunotherapy all along?
In our Ph III DELII study, 20 mg nivolumab q2w beat chemo in OS, with less toxicity, better QoL. It's time to rethink ICI dosing-for science and equity! https://t.co/mBqq2sdm6v @JCO_ASCO@OncoAlert@TataMemorial@SuyogCancer
Pleased as punch to be invited onto the Deep Margin podcast, now a fixture in HN calendar.
Privilege to follow @DavidSherMD@DrUppaluri
Great fun chatting salvage surgery with @nearlobey@will_oncology Serious topic, yet an easy listen. Do tune in https://t.co/iztg4KsqUz
@tishasaroyan I thought you nailed it, beginning with a proper history lesson, which was subsequently nicely linked to current ideology and associated flaws. Well done!
This is quite something, especially from ONE night's data. Imagine the impact if additional clinical/laboratory data were to be added! @ryanctcheong@BhikKotecha
Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌
We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.
AI learns the language of sleep🧵
On the 12th day of Christmas, IReC gave to me…12m of teamwork🤝, 11+ datasets📚, 10 team members, 9 network centres👩⚕️, 8+ papers📈, 7 studies recruiting, 6+ SCORE countries, 5 PhDs🔬, 4 governance champions, 3 BAHNO talks, 2 merged protocols✅…and 1 aim for better outcomes!
🎆New year, new papers at Nature Cancer!
The amount of tumor bacteria is now shown to influence immunotherapy outcomes in head and neck cancer in two papers out today:
🔗https://t.co/6Mc9l748PC
🔗https://t.co/c7gwXZSD8p
With the associated N&Vs:
https://t.co/yxBMGWL6rI
@DavidSherMD Gutted for you, David. My commiserations. Industry trials will always win in the current climate.
Agree the final cohort of failed first line is the interesting one to pursue in this space. Thanks for the comprehensive analysis.
“Can I bring my baby to the interview?”
The message came in at 11 PM:
“Hi, I have an interview with you tomorrow at 2 PM. My childcare fell through. Can I bring my 8-month-old? I understand if you need to reschedule.”
Old me would have rescheduled.
Unprofessional. Distraction. Red flag.
New me replied:
“Absolutely. See you tomorrow.”
She showed up with her baby on her hip.
She apologized three times before even sitting down.
Ten minutes in, the baby started crying.
She tried to soothe him while answering questions.
She apologized again.
I stopped the interview and said:
“Hey. You’re managing a fussy baby, answering complex questions, and staying calm under pressure. That’s literally the job. Handling chaos while staying professional. You’re already proving you can do it.”
Her eyes filled with tears.
We hired her.
She’s been with us for a year now.
The most reliable team member we have.
Why?
Because when you’re used to handling a screaming infant at 3 AM and still showing up to work the next day, workplace stress feels like nothing.
Working parents, especially mothers, are some of the most organized, efficient, and resilient people you’ll ever hire.
Yet we lose them because our hiring processes are built for people with zero caregiving responsibilities.
If your interview process can’t accommodate a parent facing a childcare issue, you’re not filtering for professionalism.
You’re filtering for privilege.
Reflecting on 2025, we want to extend a heartfelt thank you to our incredible network, study sites, and most importantly the patients who make research possible. Your commitment drives progress and hope for recurrent Head & Neck cancer and we are proud to work alongside you🌟
@DavidSherMD Thanks, David. Spectacular review, incisive dissection as ever. With ~45% at IVB stage (admittedly some pathN3b), thus poor tumour biology & many with large volume disease - combine this with only 85% with PDL-1 CPS>1, we have a reason for worse performance in these groups?
🚨 New Podcast Alert! Deep Margin brings you the latest in Head & Neck Oncology, hosted by IReC Deputy Director Dr Ben O’Leary and Oncologist Dr Will Ince.
👉 Listen now: https://t.co/19URqWc96I
#CancerResearch#OncologyPodcast#DeepMargin
1/3
People often ask why I seem so ‘pro’ India.
Answer is simple: in over 20 years and dozens of trips, I have NEVER once faced disrespect, negativity, backstabbing or bad energy there.
Not once!
Only love, kindness, loyalty, warmth and respect — every single time.
2/3
I’ve made lifelong friendships there that I treasure. Friends who became family. Brothers for life.
I know respect has to be earned — and I like to think I earned mine by producing the goods on the cricket field year after year, giving my everything! Whether it was against India or for an IPL team.
3/3
When a country and its people give you nothing but pure positive energy your entire adult life, that love gets returned tenfold.
India gave me its heart first.
So India will always have mine.
Forever grateful. KP ❤️