Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months.
Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions.
BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible.
Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.
YES! Humility should be as valued in our society as talent. Unfortunately, they are often not synonymous. #talentandhumility#please https://t.co/PzAYtuB7to