@Energy_Tidbits@MarkJCarney Classic Trump tactics: allow tariffs to take effect as leverage → short period of public posturing and mutual retaliation → quiet or semi-public contacts resume → a framework, partial, or full deal is announced within weeks.
Art of negotiation
#pathology looking for colon ca cases for collaborative study:
Biopsy-proven colon adenocarcinoma, post-neoadjuvant therapy, resection has neuroendocrine cells >30% of the residual tumor. There is no large case series to demontrate progrnosis. DM me if you have cases.
Cholangioblastic cholangiocarcinomas are really interesting - I am old so I like the old name!
Hissong E, et al. NIPBL::NACC1 Fusion Hepatic Carcinoma. Am J Surg Pathol. 2024 Feb 1;48(2):183-193. PMID: 38047392; PMCID: PMC11238093.
The gang in Miami sees plenty HPV-associated anal glandular lesions - but you might be missing them- check it out!
Mirzabeigi Y, et al. Expanding the Spectrum of High-Risk Human Papilloma Virus (HPV)-Associated Glandular Neoplasms of the Anorectum. Mod Pathol. PMID: 42392453.
Horrible treatment (radiation) associated epithelial changes in duodenal mucosa. The p53 can be ignored, probably reflecting upregulation rather thana mutational event. The same can be seen in the stomach.
Hutchings DA, et al PMID: 36843539; PMCID: PMC10460459.