Our paper on genetic relatedness of 4418 human diseases and traits is out! Select a disease/trait in our webtool (https://t.co/PvZdvTgvd7) and see shared genetic differences with other traits. Subtweets describe discoveries for COVID-19, gout, malaria... https://t.co/IQ7rcqlf4c
In 1998, I talked to Craig Venter about the feasibility of sequencing the human genome as a whole-genome shotgun project. Here's a story about that conversation https://t.co/ci0kyDHf43
Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful Jon Judd, and co-mentored by Jeff Spence.
What causes differences in biological sex? In our latest preprint, @_AngelaJones takes our lab in a new direction, revealing mechanisms of sex-biased gene expression and identifying abundant sex-biased eQTL throughout the genome (1/6) https://t.co/03ruCbTI9X
Finally out! We found ferroptosis inhibition reverse aging-exacerbated liver damage, and a gene signature tracks MASLD liver fibrosis and severity, and dysfunction of multi-organs, kidney, heart and pancreatic islet. A nice collab with @kuo_du, @Anna_Mae_Diehl, @denniskoHiHOST
Online now! A new study by @kuo_du et al. shows that aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress in mice.
(https://t.co/sCOiQsmEXn)
https://t.co/foD6aat3ll
Our most recent work is now published at @NatureGenet. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Great collab with @guilbourque lab and huge congrats to the lead author @katiearacena. Link: https://t.co/DxdxSVOqeg
It's a pity that All of Us used UMAP to visualize ancestry variation in their new marker paper, out today in Nature.
The UMAP algorithm, by design, exaggerates the distinctiveness of the most frequent ancestries, a message that can be misinterpreted by the public.
Watch 125,000 years of human migration in 1 minute.
The predicted spread of humans around the globe based on climate conditions over the last 125,000 years.
[📹 Tobias Friedrich]
Our latest preprint shows that how strongly a bacterial effector activates its host target is critical: “A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression” https://t.co/DIF7olIbSS