So proud to have been part of this work on cellular rejuvenation through identity-preserving reprogramming, out now in @NatureAging! Grateful to my mentors @geochurch@amplesa and all of our co-authors. https://t.co/Apu4MK6gr7
Our paper is out in @NatureAging. We looked for factors that make old cells' gene expression young without erasing their identity. SRSF1 came out as a promising rejuvenation target that reduced aging hallmarks in human cells and extended median lifespan of aged mice by 14%.
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My review on scRNAseq of diabetic wounds and our evolving understanding of fibroblast heterogeneity was published in this month's issue of @Biomed_MDPI! Grateful for wonderful mentors @LongakerLab https://t.co/g6qc4jB7uu
Can we reverse aging?
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8
Follow VitaDAO fellow @wanghelenh doing amazing research on skin wound healing.
"Thanks VitaDAO for supporting my participation at the CSHL 2022 Mechanisms of Aging meeting where I presented my exciting project "Cellular rejuvenation for skin wound healing"! #cshlaging"