Lisa Gervais

[GI Nutrition Foundation @GI_NutritionFdn]

What if the benefits of exclusive enteral nutrition for #Crohnsdisease are related to its impact on immune cells?

🆕 findings from @Bernie1234White, @PaedsRH, @KGerasimidis, @s_milling & colleagues 👇

📌 8 weeks of formula-based diet (no solid foods) impacts host immune cell profile in 9 children with #Crohnsdisease

These changes:
🔸were conserved in patients who achieved remission
🔸persisted in children who achieved remission and followed the nutrition formula consistently

💡What is new?

1⃣ EEN led to:

🔸⬇ TEMRA T cells and natural killer cells (associated with chronic inflammatory conditions)
🔸⬆ Central and effector memory CD8+ T cells (confer protection or further amplify the response at inflamed tissues)

2⃣ The impact of EEN on immune cells was independent of concomitant medication use (Azathioprine, Mesalamine, Budesonide, Prednisolone)

3⃣ Enteral nutrition led to changes in immune cells that persisted in children who achieved clinical remission or followed the nutrition formula correctly and consistently

🧑‍🔬 The authors hypothesized:

These findings are a consequence of the action of nutrition formula in decreasing the diversity of gut microbiota ➡ ⬇ recruitment of immune cells from the blood into the intestine.

🎯Now we are closer to understanding that the benefits of replacing all food and drinks with specialized liquid nutrition formulas for inducing Crohn's disease remission in children is partially related to changes in the immune system.

We look forward to upcoming research looking at the role of counterintuitive effects of EEN on gut microbiota in decreasing the activated immune response seen in Crohn's disease.

[Richard Hansen @PaedsRH]

Please take a look at this @CICRAcharity PhD fellowship opportunity at @dundeeuni with Dr Mairi McLean and myself working on IBD-related organoids. Closing date 29/03/24.
https://t.co/PtuLuBZcFq
Retweets appreciated. 🙂

[Royal Hospital for Children, Glasgow @RHCGlasgow]

📢Calling all people living with Inflammatory Bowel Disease in the UK 📢

Everyone with IBD deserves consistent, safe, high-quality, personalised care, whatever their age and wherever they live.

Take the #IBDPatientSurvey

https://t.co/4NYE8bDqiF

#IBD @IBDUKTEAM

[Royal Hospital for Children, Glasgow @RHCGlasgow]

May the 19th is #WorldIBDDay

It’s a chance for us to raise vital awareness of Crohn’s & Colitis, the two main forms of Inflammatory Bowel Disease

Our fantastic IBD Team look after around 400 patients and their families

Come and have a chat with us today at our stand today!

[The BINGO Group @BINGO_Group]

EXCITING NEW OPPORTUNITY 👩🏻‍🔬👨🏻‍🔬 for a FULLY FUNDED 💵 PhD project with ⁦@KGerasimidis⁩ and ⁦@s_milling of ⁦@MillingLab⁩ investigating the gut lung axis in paediatric respiratory disease 🦠 🍛 #PhD #diet #microbiome deadline 31/10📆 JAN start https://t.co/iJUOLyVC6n

[Lisa Gervais @weelis85]

So proud to be representing nurses and to be joined by one of our amazing patients for a talk at #PIBD2022 @espghan

[NHSGGC Paediatric Dietetic Service @nhsggcpaeddiet]

We're recruiting! 2 paediatric rotational dietetic posts available. If you have a passion for paediatrics then this is for you 👇....funding available for BDA postgrad modules, exciting specialities to work in & paediatric experience not essential. Happy to chat more on dm! 🤗

[Michelle Brooks @Michell74656510]

A rare and exciting opportunity has arisen to join our fantastic and highly innovative GI CNS team/nutrition support team! If this is you, please check out the link below, before it's too late! NHS Scotland | Jobs | Search here for your perfect career" https://t.co/W4GnsjVvjT

[Lisa Gervais @weelis85]

@AvantiWestCoast We are trying to travel from Glasgow central to London Euston today after train was cancelled last night. The trains that seem to be running this morning are shown as sold out on trainline. Can we still use our tickets on those?

[Royal Hospital for Children, Glasgow @RHCGlasgow]

Happy #IBDDay2022 💜

Our amazing IBD Team are in our atrium today raising awareness and starting a conversation about IBD through some fun activities

[Dr Vaios Svolos @VaioSvolos]

Great pleasure to present the data of our #CDTREAT trial #ECCO2022 @UofGMedicine @NHS_Lothian @NHSGGC @HelmsleyTrust @GutsCharityUK @CMF2003 @CrohnsColitisC3 @KGerasimidis @PaedsRH @carmunnock @weelis85 @jpseenan @j0nnymac1 @PhDinPoop @s_milling @stephs91 @Gwotzerho @ShahidaDin1

[Lisa Gervais @weelis85]

@Jonathansegal85 @PaedsRH Thank you ☺.

[Richard Hansen @PaedsRH]

This small open access study from @kgikas10 @KGerasimidis & colleagues from @BINGO_Group at @UofGlasgow looks at potential dietary triggers of #Crohns gut inflammation and implicates fibre, gluten-containing cereal and red/processed meat. #IBD https://t.co/UUbMWahzTC

[Kostas Gerasimidis @KGerasimidis]

Exciting fully funded PhD studentship studying the role of microbiome and it interaction with nutrition in the gut-lung axis! https://t.co/R1dhXXfcYc
microbes-viruses-and-immunity/?p137093

[Dr Vaios Svolos @VaioSvolos]

👩‍🔬👨‍🔬Join our team @BINGO_Group @UofGMVLS @UofGMedicine @NHSGGC @kgikas10 @KGerasimidis @PaedsRH

🧪@CrohnsColitisFn funded #postdoc opportunity for 3y
🧪multicentre UK study
🧪explore #diet & #microbiome triggers #crohnsdisease
🧪Closes 18/03/21

https://t.co/59fPcQUqg6

[GlasgowCRF @GlasgowCRF]

Are you a paediatric/neonatal nurse looking for a change? We're recruiting! Come and join our Children's CRF team! 👇 https://t.co/ge0oMkTEfV

@SRNCN1 @NHSResearchScot @NIHR_UKCRFN @RHCGlasgow

[The Herald @heraldscotland]

After eight weeks, 60% of patients had gone into remission and 80% of participants had improved clinically.
https://t.co/Nn29WommlO

[GlasgowCRF @GlasgowCRF]

Team all ready to go this morning @RHCGlasgow for a weekend of recruitment to the RAPID-19 study #COVID19
We've had a fantastic response from our HCW families 🙂🙏 thank you
@redfernjam @jenfrodgers @NHSGGC @NHSResearchScot

[The BINGO Group @BINGO_Group]

What a great night we had at @CMF2003 #redhotball 2020 @PaedsRH @vgarrick4 @ElaineB06659046 @kgikas10 @KGerasimidis @j0nnymac1 @carmunnock @weelis85 @Michell74656510