Great work from Aldis Weible and Amanda Stebritz, laying the groundwork for research to understand how cortical circuitry is damaged in AD, and how this can best inform behavioral gap detection measures for use as AD biomarkers. (3/3)
Delighted to share our first study showing how sound processing in auditory cortex is disrupted in an Alzheimerβs mouse model. These early-onset impairments help explain behavioral deficits that could be an early diagnostic biomarker for Alzheimerβs. (1/3) https://t.co/AM7rzJUhkS
We found that 5XFAD mice have early-onset auditory dysfunction (i.e. gap detection deficits). In auditory cortex, firing rates were robustly and progressively degraded as early as 2-4 months. This is long before memory, cognitive, or other behavioral deficits appear. (2/3)
DLC-Live! and Autopilot are ~release twins~ today! I just pushed v0.3.0, which includes DLC-Live integration for realtime markerless tracking and about a thousand more commits of cool stuff for ya. a thread: /1
pypi: https://t.co/C4RIWgfoiW
release notes: https://t.co/TSb3t5isiC
3. This system is perfect for monitoring the eyes, ears, whiskers, face, and/or visual field during freely-moving behavior. We also include a ton of practical tips & tricks for building your own multi-camera headsets, along with step-by-step instructions.
1. Excited to share our new preprint, βA head-mounted multi-camera system for electrophysiology and behavior in freely-moving mice,β great work by Nick Sattler:
https://t.co/hEILSMVRlz
2. We describe a couple versions of a head-mounted multi-camera system based on tiny analog camera modules (each is 180 mg, US$23, 5 mm) and designed around an Intan headstage for high-density electrophysiology.
2. We describe a couple versions of a head-mounted multi-camera system based on tiny analog camera modules (each is 180 mg, US$23, 5 mm) and designed around an Intan headstage for high-density electrophysiology.
https://t.co/dkEtWcJ6Qb
@SwannLab Yes, we have gotten from not discussed to funded. Make it better, resubmit, persevere. And try not to take it personally, it's just part of the process.
Here's cricket velocity (being chased by a mouse during prey capture in our lab) plotted with joyPlot.m, in honor of the 40th anniversary of the eruption of Mt. St. Helens.
Congrats to Jonny, special guest at the DeepLabCut hackathon who helped the team bring to life real-time DeepLabCut for closed-loop tracking. This is going to be an amazing tool!
Bonsai 2.5 + real-time DeepLabCut! You can now connect live tracking to your hardware in closed-loop. Install from: https://t.co/HzZjhx18Xy, DLC GPU install instructions at: https://t.co/cPqWU1fwzw
Today we're releasing Autopilot - a Python framework for performing complex behavioral experiments by distributing them over swarms of Raspberry Pis. Let me tell you how we've rewritten what you should consider possible in your experiments /1
site: https://t.co/yg6e8af1aN