Wei-Feng Xue

wfxue lab - biophysics, proteins, bio-maths, nano-imaging and multidisciplinary science

[Wei-Feng Xue @wfxue_lab]

Exciting updates in the near future that we are currently working on include algorithms for better AFM height image deconvolution, integration with cryo-EM maps, and multimodal mapping.

[Wei-Feng Xue @wfxue_lab]

Trace_y is finally in the press! https://t.co/kOawl54IIS🔬💡💡💡
This is an open-source software tool for 3D contact point reconstruction AFM that enables 3D structural reconstruction of individual helical filaments.

[Wei-Feng Xue @wfxue_lab]

It allows reconstruction of one 3D model from one single observation of one individual filament, and this is useful for example for the analysis of amyloid polymorph distributions and rare species. Try it out here: https://t.co/dAksoO1Mw0.

[Wei-Feng Xue @wfxue_lab]

Also proud to share the individual filament structural reconstruction tools that enabled analysis of polymorph distributions and rare spacies https://t.co/dAksoO1Mw0 https://t.co/kH5wjDktw2 #bioRxiv #biorxiv_biophys! 👍 #AFM + #cryoEM integration 🔬💡💡💡

[Wei-Feng Xue @wfxue_lab]

Proud to share our new pre-prints on #bioRxiv #biorxiv_biophys! Discovery of rare structures in complex and heterogeneous amyloid polymorph distributions https://t.co/CYcLrqeXgB Awesome work @LDAubrey @LiisaLutter and amazing collaboration @SerpellLab Thank you @Serpell1! 💡💡💡

[bioRxiv Biophysics @biorxiv_biophys]

Structural reconstruction of individual filaments in Abeta42 fibril populations assembled in vitro reveal rare species that resemble ... https://t.co/uMFTB7Rweg #biorxiv_biophys

[bioRxiv @biorxivpreprint]

Structural reconstruction of individual filaments in Abeta42 fibril populations assembled in vitro reveal rare species that resemble ex vivo amyloid polymorphs from human brains https://t.co/sk7n20u9Wb #bioRxiv

[bioRxiv @biorxivpreprint]

Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy https://t.co/HMRxRbf9kF #bioRxiv

[bioRxiv Biophysics @biorxiv_biophys]

Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point ... https://t.co/FMkT2zDiFq #biorxiv_biophys

[Wei-Feng Xue @wfxue_lab]

Fantastic research away day with the @SerpellLab last week, was great to meet and chat about exciting new developments in the amyloid research field after an inspirational FASEB #pacsrc. Thank you @Serpell1! 💡💡💡

[Wei-Feng Xue @wfxue_lab]

Amazing! Well-done @LDAubrey !

[RadfordLab @RadfordLab]

So proud to hear that Liam won a poster prize at this weeks FASEB meeting on proton aggregation in Dublin for his super exciting data on amyloid fuzzy coats. Well done Liam!!

[Wei-Feng Xue @wfxue_lab]

Amazing meeting! It's such a pleasure to be part of this meeting, my first in person science meeting experience since the pandemic. 🔬💡😊

[Switch Lab @VIB_Switch_Lab]

#ProAgg22 kicked off at this afternoon. Switch Lab PIs Frederic Rousseau and Joost Schymkowitz welcomed the delegates and we had an afternoon of amazing talks. #proteinaggregation is buzzing in Leuven today!

[Switch Lab @VIB_Switch_Lab]

#ProAgg22 kicked off at this afternoon. Switch Lab PIs Frederic Rousseau and Joost Schymkowitz welcomed the delegates and we had an afternoon of amazing talks. #proteinaggregation is buzzing in Leuven today!

[Chris Serpell @CJSerpell]

Interested in using DNA nanotech to control amyloid assembly and biology? @wfxue_lab and I have a postdoc position for you: https://t.co/l7sNNJPXOz Please RT @ChemPostdocBot #ukchemjobs

[Chris Serpell @CJSerpell]

Controlling amyloid assembly and biological function with DNA nanotech? I'll have a postdoc ad out shortly with @wfxue_lab @biokent @KentSISC #ukchemjobs #chempostdoc

[Switch Lab @VIB_Switch_Lab]

#ProAgg22:
We are organising a conference this September. Check out the exciting speakers who will share their research in the first edition of the Leuven Protein Aggregation Meeting!
https://t.co/0R3klXyNkH
with @RadfordLab @PPMC_UAB @SerpellLab @DellaDavid_Lab and more!

[Dr Youssra Al-Hilaly @YoussraHilaly]

It was such a great work @SerpellLab , and a great collaboration with @wfxue_lab @JMolBiol @TauRx @SussexNeuro

[Wei-Feng Xue @wfxue_lab]

Linking structural information from individual particle AFM with high-resolution Cryo-EM: https://t.co/gb3GaRcvbe Fantastic work by @LiisaLutter and amazing collaboration with the @SerpellLab @Serpell1 🔬💡💡💡

[Wei-Feng Xue @wfxue_lab]

@SjorsScheres @AbhayKot @MichelGoed We are also really pleased and grateful that our prediction on the dGAE tau structure through our new AFM methodological developments is validated. https://t.co/Qf13MvjntV @SerpellLab @LiisaLutter 😊🔬💡

[Wei-Feng Xue @wfxue_lab]

@SjorsScheres @AbhayKot @MichelGoed Amazing cryo-EM work 👍! It really highlights the fascinating polymorphic nature of amyloid 🔬💡.