wigglethemouse

49ers and Swindon Town supporter. Engineer. #mecfs has got in the way of having a life

[wigglethemouse @wigglethemouse]

@VirusesImmunity May I ask why "if replicated" if the same has already been shown in ME/CFS by the research team led by Dr Jackie Cliff a number of years ago - they used digital droplet PCR of saliva? We need to move faster.

[ME/CFS Science @mecfsskeptic]

Very impressive work by Paolo Maccallini. 👇

"Gene-set analysis identified multiple neuronal and synaptic gene sets, several of which were independently replicated, with glutamatergic synapses as the most specific replicated signal."

Will do a detailed summary later.

[wigglethemouse @wigglethemouse]

@violinvet Congratulations for all those years of work. Glad you were able to make Graduation!!!!!

[wigglethemouse @wigglethemouse]

@Sally_writes Same here. I need to spend my very limited energy on the little joys. Very grateful for those that advocate.

[wigglethemouse @wigglethemouse]

@Sally_writes He's watching the owl! 😉

[wigglethemouse @wigglethemouse]

@susan_mecfs @DanMissailidis That's an interesting paper possibly supporting the observation of immune changes over time of the illness.

[wigglethemouse @wigglethemouse]

@Z3R0Gravitas I think E would be nice framed. My favorite due to mix of colours

[wigglethemouse @wigglethemouse]

@JackHadfield14 Mast cells also have receptors that release Granzyme just like Killer T and NK cells. That kinda blew my mind.

[wigglethemouse @wigglethemouse]

@violinvet @Naomi_D_Harvey Yep. We got sunblock curtains and I reacted to the smell of them 😂
Six months airing in the garage before we hung them up.

[wigglethemouse @wigglethemouse]

@violinvet @Naomi_D_Harvey Thanks for the feedback both of you. It was good to be reminded that repeated exposure can desensitize the skin somewhat sometimes.
Sunblock clothes and good quality sensitive skin sunblock can help too. Unless you start reacting to the sunblock as well.

[wigglethemouse @wigglethemouse]

@JackHadfield14 Sorry if I missed it what is the outer green line? Is it 3 standard deviations above high normal or something like that?

[wigglethemouse @wigglethemouse]

@violinvet @Naomi_D_Harvey I'm allergic to the sun since 2000. Did you have any thoughts on what might have caused it and why it disappeared E.g. perhaps a medication making you sun sensitive?

[wigglethemouse @wigglethemouse]

@Z3R0Gravitas @Naomi_D_Harvey @clarejdaly I don't get much light all year round but I do get seasonal changes. Leaves appearing on trees and leaves disappearing from trees are two very stark downturns for me. Second week March, second week October.

Mike Snyder had a very good seasonal study a few years ago.

[wigglethemouse @wigglethemouse]

@Sally_writes ❤️❤️❤️. That marketing career is being put to good use. 😍

[wigglethemouse @wigglethemouse]

@nwagoner Fred said it wasn't up to him, it was a business decision. 49ers insure their top wages. Could he need to meet an insurance demand before returning? Reinjury could be a significant cost for the insurer.

How do these policies work?

[Maureen Hanson @DrMaureenHanson]

In pre-2020 ME cases, analysis of over 7000 proteins demonstrates that exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial metabolism in comparison to healthy sedentary controls. Protein signatures correlate with symptom severity.

[wigglethemouse @wigglethemouse]

@mecfsskeptic I would say for neurological/peripheral nerve effects sjogrens is a close match.

[wigglethemouse @wigglethemouse]

@lifeanalytics @OpenMedF I thought that summary was fascinating. You don't normally write 3 papers for null results. Fingers crossed. And this work has been progressing for quite a number of years.

I'm looking forward to see how well the radioisotope labelling worked that was on previous web version.

[Michael R Scoma MD @DrMichaelScoma]

Severe and very severe ME/CFS patients are the sickest patients I’ve ever seen - even compared to septic transplant or end-stage cancer patients.

The unrelenting suffering and lack of research or definitive treatments puts severe ME/CFS on another level. Nothing compares...