Hello folks, I just published my new newsletter: "Kanna Journeys".
An update around my new offerings with the herbal medicine of Kanna & more.
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https://t.co/dOCZ8CxcK9
Most people hear "DMT" and think aliens, machine elves, interdimensional portals.
The esoteric reputation is so dominant that it overshadows something far more practical…
nn-DMT might be the most effective acute treatment for the most painful condition known to medicine.
Cluster headaches are called "suicide headaches" for a reason. The pain is rated worse than cancer, broken bones, and childbirth. Suicidal ideation occurs in 55% of patients. Attacks hit up to eight times a day. And for the chronic variant, there is no approved medication on the market.
Psilocybin and LSD can help prevent cycles, and the data there is strong.
But they have a practical limitation: onset time. If you're woken at 3am with pain boring into your eye socket, you can't wait 45 minutes for psilocybin to kick in or commit to 6 to 12 hours of altered consciousness.
Enter the DMT vape pen.
Bob Wold, founder of Clusterbusters, describes it simply: one inhalation, pain gone in 30 seconds.
Joe McKay, a retired NYC firefighter and longtime sufferer, keeps one at his bedside. Takes a hit during a nighttime attack and is back asleep within minutes. He returned all his oxygen equipment after years of relying on it.
The pharmacology is almost tailor-made for this use case. Onset in seconds with a duration of 10 to 15 minutes. It works at sub-perceptual doses with no tolerance buildup. A single cartridge treats 40 to 50 attacks.
The whole thing fits in your pocket.
The mechanism of action makes sense too.
DMT is a serotonin 2A receptor agonist, structurally similar to the triptans already prescribed for cluster headaches. The difference is that conventional triptans don't abort cluster cycles or extend remission the way psychedelic tryptamines appear to.
Same receptor family, but psychedelics seem to do something the pharmaceuticals can't.
What would it look like if every cluster headache patient had access to a DMT vape pen that could end their worst attacks in seconds?
Picture below is from the underground market.
Polish 26 year old guitar master Marcin Patrzałek respond to those who have made public comments claiming that his music is fake.
He made this video in a tutorial form showing how he manages to play so extraordinarily well in response. And yes, it's all played on one guitar.
Scientist discover a mushroom that makes you see thousands of tiny people everywhere.
The tiny people often interact with the subject in intelligent ways. 😳 🍄
@OsheaJacksonJr I remember watching this live from a bar in Paris, tears streaming. So so good.
I’m as sure now as I was then that the massive shadow projection of Prince playing his glorious guitar cock was a colossal FU to the nipplegate nonsense. Rest in Glory and Grace. 💜
Never let anyone tell you:
You can't be productive on LSD.
Just listen to Jefferson Airplane perform White Rabbit...after accidentally snorting PURE LSD!
Her vocals at the end are🤯🤯🤯
A performance that still gives us chills decades later.
David Bowie and Annie Lennox honoring Freddie Mercury with "Under Pressure" is pure rock history.